2-氟-2-磷酰基乙酸三乙酯合成路线 （共 33 条）
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=20°C; 1.5 h;
2: isovaleraldehyde in tetrahydrofuran
参考文献
Bargiggia, Frederic; Piva, Olivier
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1819 - 1827
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester Alkaline hydrolysis;
2: tert-butyl alcohol With 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
参考文献
Sano, Shigeki; Yokoyama, Kenji; Teranishi, Rie; Shiro, Motoo; Nagao, Yoshimitsu
Tetrahedron Letters, 2002 , vol. 43, # 2 p. 281 - 284
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With sodium hydride in diethyl ether
T=-5°C; 0.0833333 h;
2: cyclohexanone With Wadsworth-Horner-Emmons reagent in diethyl ether
4 h;
参考文献
Van Der Veken, Pieter; Senten, Kristel; Kertesz, Istvan; De Meester, Ingrid; Lambeir, Anne-Marie; Maes, Marie-Berthe; Scharpe, Simon; Haemers, Achiel; Augustyns, Koen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1768 - 1780
