5-氮杂-2'-脱氧胞嘧啶核苷合成路线 （共 14 条）
反应条件
1: 5-aza-cytosine With N,O-bis(trimethylsilyl) trifluoroacetamide in acetonitrile T=50°C; 1.5 h; 2: Hoffer's chlorosugar With trimethylsilyl trifluoromethanesulfonate in acetonitrile T=20°C; 2.5 h; 3: With methanol; sodium methylate T=50°C; 1 h;
参考文献
EP2371825 A1, ;
Page/Page column 9 ;
反应条件
1: 5-aza-cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Heating / reflux; 2: 3,5-di-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl chloride With lithium trifluoromethane sulfonate in dichloromethane T=20 - 25°C; 4 h; 3: With ammonia; water; sodium hydrogencarbonate more than 3 stages;
参考文献
EP2048151 A1, ;
Page/Page column 3 ;
反应条件
1: With trifluorormethanesulfonic acid in acetonitrile T=0°C; 24 h; 2: With methanol; sodium methylate in dimethyl sulfoxide; acetonitrile T=20 - 23°C;
参考文献
US2010/36112 A1, ;
Page/Page column 7-8 ;
反应条件
ammonia Alcoholic medium;
参考文献
Cilag AG
Patent: EP2050757 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
sodium methylate in methanol T=20°C; 4 h; Inert atmosphere;
参考文献
US2010/249394 A1, ;
Page/Page column 6 ;
反应条件
methanol; ammonia T=10 - 20°C; Product distribution / selectivity;
参考文献
WO2010/129211 A2, ;
Page/Page column 28 ;
反应条件
T=150°C; 0.166667 h; Neat (no solvent); Product distribution / selectivity;
参考文献
US2006/14949 A1, ;
Page/Page column 6; 15 ;
反应条件
in methanol T=20°C; 240 h; Product distribution / selectivity;
参考文献
US2006/14949 A1, ;
Page/Page column 15 ;
反应条件
T=37°C; pH 9.5; other temperature, pH; decomposition of 5-aza-2'-deoxycytidine and 5-azacytidine on alkali and neutral solutions, HPLC study; Rate constantProduct distribution;
参考文献
Journal of Pharmaceutical Sciences, , vol. 70, # 11 p. 1228 - 1232
反应条件
water T=20°C; Acidic aqueous solution;
参考文献
Phiasivongsa, Pasit; Redkar, Sanjeev
Patent: US2006/205685 A1, 2006 ;
Location in patent: Page/Page column 4; sheet 3 ;
