1: (S)-2-methyl-1-butyl bromide With magnesium in tetrahydrofuran Inert atmosphere; 2: 3-chloropropyl tosylate With dilithium tetrachlorocuprate in tetrahydrofuran T=-70 - 20°C; Inert atmosphere;

1.1: pyridine / 3 h / 0 - 5 °C 2.1: lithium bromide / N,N-dimethyl-formamide / 1 h / 60 °C 3.1: magnesium / tetrahydrofuran / Inert atmosphere 3.2: -70 - 20 °C / Inert atmosphere View Scheme

1.1: lithium bromide / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: magnesium / tetrahydrofuran / Inert atmosphere 2.2: -70 - 20 °C / Inert atmosphere View Scheme

thionyl chloride; N,N-dimethyl-aniline