2-氨基-5-巯基-1,3,4-噻二唑合成路线 （共 50 条）
反应条件
potassium hydroxide in ethanol
Reflux;
参考文献
Cho, Nam Sook; Hwang, Hye-Jeong; Suh, Il-Hwan; Kang, Sung Kwon
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 5 p. 1393 - 1396
反应条件
piperidine in ethanol
4 h; Heating;
参考文献
Okabe; Bhooshan; Novinson; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 3 p. 735 - 751
反应条件
N-benzyl-N,N,N-triethylammonium chloride
T=90°C; 0.166667 h; neat (no solvent);
参考文献
Mobinikhaledi; Jabbarpour; Hamta
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 3 p. 812 - 814
反应条件
1: 5-amino-2-mercapto-1,3,4-thiadiazole With potassium hydroxide in ethanol
0.166667 h;
2: 2-bromo-1-ethanol in ethanol
2 h;
参考文献
Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560
反应条件
sodium hydroxide in ethanol; water
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY Co., Ltd.
Patent: EP282635 A3, 1989 ;
反应条件
potassium hydroxide in ethanol
参考文献
Eli Lilly and Company
Patent: US3990879 A1, 1976 ;
反应条件
sodium hydroxide in methanol; water
T=20°C; 10 h;
参考文献
Zhao, Jie; Chen, Bao Quan; Shi, Yan Ping; Liu, Yu Ming; Zhao, Hai Chuan; Cheng, Ji
Chinese Chemical Letters, 2012 , vol. 23, # 7 p. 817 - 819
参考文献
Gulf Oil Corporation
Patent: US4097263 A1, 1978 ;
反应条件
potassium hydroxide in ethanol
T=20°C; 1 h;
参考文献
Bourdais; Dauvillier; Gayral; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 233 - 239
反应条件
potassium carbonate in acetonitrile
T=20°C; 15 h;
参考文献
VANDERBILT UNIVERSITY; CONN, P. Jeffrey; LINDSLEY, Craig W.; HOPKINS, Corey R.; WEAVER, Charles David; NISWENDER, Colleen M.; GOGLIOTTI, Rocco D.; CHEUNG, Yiu-Yin; SALOVICH, James M.; ENGERS, Darren W.
Patent: WO2011/143466 A1, 2011 ;
Location in patent: Page/Page column 70 ;
WO 2011/143466 A1
