2-氨基-5-巯基-1,3,4-噻二唑合成路线 （共 50 条）
反应条件
1: 5-amino-2-mercapto-1,3,4-thiadiazole With potassium hydroxide in ethanol
0.166667 h;
2: 1-bromomethyl-4-methoxy-benzene in ethanol
2 h;
参考文献
Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560
反应条件
in toluene
1 h; Heating;
参考文献
Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20
反应条件
in methanol
1 h; Heating;
参考文献
Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20
反应条件
Amberlite(R) IRA-67 in acetonitrile
T=20°C; 24 h;
参考文献
Shen, Li-Hong; Li, Hong-Yu; Shang, Hui-Xia; Tian, Shu-Ting; Lai, Yi-Sheng; Liu, Li-Jie
Chinese Chemical Letters, 2013 , vol. 24, # 4 p. 299 - 302
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
反应条件
sodium hydroxide in ethanol
T=20°C; 12 h;
参考文献
Radi, Marco; Crespan, Emmanuele; Falchi, Federico; Bernardo, Vincenzo; Zanoli, Samantha; Manetti, Fabrizio; Schenone, Silvia; Maga, Giovanni; Botta, Maurizio
ChemMedChem, 2010 , vol. 5, # 8 p. 1226 - 1231
反应条件
sodium hydroxide in ethanol; water
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY Co., Ltd.
Patent: EP282635 A3, 1989 ;
反应条件
sodium hydroxide in ethanol
T=20°C; 24 h;
参考文献
Shen, Li-Hong; Li, Hong-Yu; Shang, Hui-Xia; Tian, Shu-Ting; Lai, Yi-Sheng; Liu, Li-Jie
Chinese Chemical Letters, 2013 , vol. 24, # 4 p. 299 - 302
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; 0.5 h;
参考文献
FUJIFILM Corporation; TATEISHI Keiichi; FUJIE Yoshihiko; TAKESHIMA Youichirou
Patent: EP2660293 A1, 2013 ;
Location in patent: Paragraph 0089 ;
