4-羟基-6-甲氧基喹啉合成路线 （共 23 条）
反应条件
potassium carbonate; palladium; cis-maleic acid Reagens 4: Palladium/Kohle, Reagens 5: Wasser;
参考文献
Journal of the American Chemical Society, , vol. 71, p. 1906,1910
反应条件
1: acetic acid; aqueous hydrochloric acid 2: maleic acid; potassium carbonate; palladium / Reagens 4: Palladium/Kohle, Reagens 5: Wasser View Scheme
参考文献
Journal of the American Chemical Society, , vol. 71, p. 1906,1910
反应条件
1: 86 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 2: 94 percent / NaI; Et3N / acetonitrile / 1 h / Heating 3: 98 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 4: 98 percent / aq. NaOH / methanol / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 13 p. 3017 - 3035
反应条件
1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 86 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 3: 94 percent / NaI; Et3N / acetonitrile / 1 h / Heating 4: 98 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 5: 98 percent / aq. NaOH / methanol / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 13 p. 3017 - 3035
反应条件
1: 94 percent / NaI; Et3N / acetonitrile / 1 h / Heating 2: 98 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 3: 98 percent / aq. NaOH / methanol / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 13 p. 3017 - 3035
反应条件
1: 98 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 2: 98 percent / aq. NaOH / methanol / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 13 p. 3017 - 3035
反应条件
sulfuric acid T=125°C;
参考文献
Zhurnal Obshchei Khimii, , vol. 7, p. 1896,1904
Chem. Zentralbl., , vol. 109, # I p. 3774
反应条件
phosphorus tribromide in water; N,N-dimethyl-formamide T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/16610 A2, 2007 ;
Location in patent: Page/Page column 31 ;
反应条件
1.1: phosphorus tribromide / N,N-dimethyl-formamide / 2 h / 20 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether / -78 °C 2.2: 3 h / -78 °C View Scheme
参考文献
Tukulula, Matshawandile; Little, Susan; Gut, Jiri; Rosenthal, Philip J.; Wan, Baojie; Franzblau, Scott G.; Chibale, Kelly
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 259 - 267
参考文献
Davies, David Thomas; Jones, Graham Elgin; Peightfoot, Andrew; Markwell, Roger Edward; Pearson, Neil David
Patent: US2004/38998 A1, 2004 ;
