4-羟基-6-甲氧基喹啉合成路线 （共 23 条）
反应条件
in dowtherm A T=255°C; 0.0833333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/16610 A2, 2007 ;
Location in patent: Page/Page column 31 ;
参考文献
US2719848 , ;
Journal of the American Chemical Society, , vol. 68, p. 1204,1206
Organic Syntheses, , vol. Coll. Vol. III, p. 272
反应条件
1: With orthoformic acid triethyl ester in ethanol 2 h; Heating / reflux; 2: With diphenylether 0.0333333 h; Heating / reflux;
参考文献
WO2006/21448 A1, ;
Page/Page column 88-89 ;
反应条件
1.1: toluene / 1 h / Heating 1.2: 36 percent / diphenyl ether / 1 h / Heating 2.1: aq. sodium hydroxide / 1 h / Heating 3.1: diphenyl ether / 1 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 5 p. 821 - 824
反应条件
sodium hydroxide in methanol Heating;
参考文献
Theeraladanon, Chumpol; Arisawa, Mitsuhiro; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron, 2004 , vol. 60, # 13 p. 3017 - 3035
反应条件
sodium hydroxide 1.) reflux, 5 h, 2.) Ph2O, 250 deg C, 5 min; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 3 p. 735 - 746
反应条件
1: aq. sodium hydroxide / 1 h / Heating 2: diphenyl ether / 1 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 5 p. 821 - 824
参考文献
Journal of the American Chemical Society, , vol. 68, p. 2685
Zhurnal Obshchei Khimii, , vol. 13, p. 697,700
Chem.Abstr., , p. 704
Journal of the American Chemical Society, , vol. 68, p. 113,115
Justus Liebigs Annalen der Chemie, , vol. 568, p. 73,79
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione With orthoformic acid triethyl ester T=145°C; 2: 4-methoxy-benzaldehyde T=50 - 145°C; 3: in diphenylether T=250°C;
参考文献
Journal of Organic Chemistry, , vol. 72, # 6 p. 2232 - 2235
反应条件
1: diphenyl ether biphenyl mixture 2: aqueous HCl 3: 275 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1204,1206
Organic Syntheses, , vol. Coll. Vol. III, p. 272
