5,7-二-(苄氧基)-2-(4-(苄氧基)苯基)-3-羟基-4H-苯并吡喃-4-酮合成路线 （共 12 条）
反应条件
1: With 3,3-dimethyldioxirane in dichloromethane; acetone T=0°C; 2: With toluene-4-sulfonic acid in dichloromethane T=0°C; 0.5 h;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: WO2006/86103 A2, 2006 ;
Location in patent: Page/Page column 4-5; 25; 34 ;
WO 2006/086103 A2
反应条件
1.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C 2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C 2.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 22 p. 5149 - 5152
反应条件
1.1: 75 percent / K2CO3 / acetone / 6 h / Heating 2.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C 3.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C 3.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 22 p. 5149 - 5152
反应条件
1.1: 75 percent / K2CO3 / acetone / 6 h / Heating 2.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C 3.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C 3.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 22 p. 5149 - 5152
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: sodium hydride / N,N-dimethyl-formamide / 20 °C 3: iodine / dimethyl sulfoxide / 110 °C 4: 3,3-dimethyldioxirane / dichloromethane; acetone / 0 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 1 p. 17 - 21
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 20 °C 2: iodine / dimethyl sulfoxide / 110 °C 3: 3,3-dimethyldioxirane / dichloromethane; acetone / 0 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 1 p. 17 - 21
反应条件
1: iodine / dimethyl sulfoxide / 110 °C 2: 3,3-dimethyldioxirane / dichloromethane; acetone / 0 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 1 p. 17 - 21
反应条件
1: acetic acid / water / 110 °C 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C 3: methanol; sodium methylate / 5 h / 20 °C 4: hydrogen; palladium(II) oxide hydrate / tetrahydrofuran; methanol / 6 h / 20 °C View Scheme
参考文献
Yamasaki, Kazuaki; Hishiki, Ryogo; Kato, Eisuke; Kawabata, Jun
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 17 - 21
反应条件
1: 85 percent / PPh3 / Pd2(dba)3*CHCl3 / CH2Cl2 / 3 h / 0 °C 2: 73 percent / NaBH4 / CH2Cl2; methanol / 3 h / -78 °C 3: 96 percent / OsO4; NMO / acetone; 2-methyl-propan-2-ol; H2O / 3 h / 0 °C 4: 80 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 3 h / 20 °C View Scheme
参考文献
Shan, Mingde; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
反应条件
hydrogen; palladium(II) oxide hydrate in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
Yamasaki, Kazuaki; Hishiki, Ryogo; Kato, Eisuke; Kawabata, Jun
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 17 - 21
