2-甲硫基-5-苯基-1,3,4-二唑合成路线 （共 18 条）
反应条件
(NH4)6[Mo7O24]*4H2O; dihydrogen peroxide in ethanol T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
Toda, Narihiro; Asano, Shigehiro; Barbas, Carlos F.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12592 - 12596
Angew. Chem., 2013 , vol. 125, # 48 p. 12824 - 12828,5
反应条件
1: aq. KMnO4; glacial acetic acid / 6 h 2: hydrazine hydrate / dioxane; diethyl ether / 4.5 h / cooling View Scheme
参考文献
Qiu, Zao-Zao; Dai, Chao-Feng; Chao, Shu-Jun; Xu, Peng-Fei; Zhang, Zi-Yi
Journal of the Chinese Chemical Society, 2004 , vol. 51, # 6 p. 1343 - 1346
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=18 - 25°C; 16 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/11130 A2, 2008 ;
Location in patent: Page/Page column 171-172 ;
WO 2008/011130 A2
反应条件
copper diacetate; silver fluoride in N,N-dimethyl-formamide
T=140°C; 15 h; Inert atmosphere;
参考文献
Dai, Chao; Xu, Zhaoqing; Huang, Fei; Yu, Zhengkun; Gao, Yan-Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4414 - 4419
参考文献
Madhavan,R.; Srinivasan,V.R.
Indian Journal of Chemistry, 1969 , vol. 7, p. 760 - 765
参考文献
Alam; Koldobskii
Russian Journal of Organic Chemistry, 1997 , vol. 33, # 8 p. 1149 - 1155
反应条件
2: aq.-ethanolic NaOH
View Scheme
参考文献
Hoggarth
Journal of the Chemical Society, 1952 , p. 4811,4817
反应条件
1: 78 percent / dimethylformamide / 1 h
2: 28 percent / SOCl2 / 2 h / Heating
View Scheme
参考文献
Kassem
Pharmazie, 1990 , vol. 45, # 6 p. 435 - 436
反应条件
1: hydrazine hydrate / methanol
2: potassium hydroxide / ethanol / |Reflux
3: sodium hydroxide
View Scheme
参考文献
Li, Pei; Yin, Juan; Xu, Weiming; Wu, Jian; He, Ming; Hu, Deyu; Yang, Song; Song, Baoan
Chemical Biology and Drug Design, 2013 , vol. 82, # 5 p. 546 - 556
反应条件
1: sulfuric acid
2: hydrazine hydrate / methanol
3: potassium hydroxide / ethanol / |Reflux
4: sodium hydroxide
View Scheme
参考文献
Li, Pei; Yin, Juan; Xu, Weiming; Wu, Jian; He, Ming; Hu, Deyu; Yang, Song; Song, Baoan
Chemical Biology and Drug Design, 2013 , vol. 82, # 5 p. 546 - 556
