1-甲基-5-氨基吡唑-4-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrazine hydrate in ethanol T=0 - 80°C;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
hydrazine hydrate in acetic acid 0.5 h; Heating;
参考文献
Huppatz, John L.
Australian Journal of Chemistry, 1985 , vol. 38, # 1 p. 221 - 230
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Alberola; Antolin; Gonzalez; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1035 - 1038
反应条件
1: 15 percent / NaOH / aq. ethanol / Ambient temperature 2: 82 percent / aq. HCl / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, # 4 p. 1035 - 1038
参考文献
Chemische Berichte, , vol. 89, p. 1652,1656
反应条件
hydrogenchloride; sodium nitrite in water
T=0 - 5°C; 0.75 h;
参考文献
Ege, Guenter; Gilbert, Karlheinz; Heck, Reinhard
Chemische Berichte, 1984 , vol. 117, # 5 p. 1726 - 1747
反应条件
hydrogenchloride in ethanol
T=60 - 80°C; 2 h;
参考文献
Huppatz, John L.
Australian Journal of Chemistry, 1985 , vol. 38, # 1 p. 221 - 230
反应条件
1: 80 percent / conc. hydrochloric acid / ethanol / 2 h / 60 - 80 °C
2: 85 percent / 10percent NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Huppatz, John L.
Australian Journal of Chemistry, 1985 , vol. 38, # 1 p. 221 - 230
反应条件
1: 80 percent / conc. hydrochloric acid / ethanol / 2 h / 60 - 80 °C
2: 85 percent / 10percent NaOH / ethanol / 1 h / Heating
3: SOCl2 / Heating
View Scheme
参考文献
Huppatz, John L.
Australian Journal of Chemistry, 1985 , vol. 38, # 1 p. 221 - 230
反应条件
1: conc. HCl, NaNO2 / H2O / 0.75 h / 0 - 5 °C
2: triethylamine / CH2Cl2 / 1 h
3: lead(IV) acetate / CH2Cl2 / 0.25 h / 0 - 5 °C
View Scheme
参考文献
Ege, Guenter; Heck, Reinhard; Gilbert, Karlheinz; Irngartinger, Hermann; Huber-Patz, Ursula; Rodewald, Hans
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1629 - 1639
