(2S)-2-氨基-4-戊炔酸合成路线 （共 22 条）
反应条件
1: BPB hydrochloride With Ni(NO3)2·6H2O; sodium hydride; glycine; potassium hydroxide in methanol T=50°C; 2 h; Inert atmosphereReflux; 2: propargyl bromide With tetra-(n-butyl)ammonium iodide; sodium hydroxide in dichloromethane; water T=20°C; 1 h; 3: With hydrogenchloride in methanol; water 2 h; Reflux;
参考文献
Lee, Dong Jun; Mandai, Kalyaneswar; Harris, Paul W. R.; Brimble, Margaret A.; Kent, Stephen B. H.
Organic Letters, 2009 , vol. 11, # 22 p. 5270 - 5273
反应条件
T=37°C; 21 h; kidney acylase;
参考文献
Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael
Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
参考文献
Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael
Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
反应条件
lithium hydroxide in tetrahydrofuran T=0°C; 1 h;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 11 p. 1967 - 1977
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
参考文献
Journal of the American Chemical Society, , vol. 111, # 16 p. 6354 - 6364
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
参考文献
Journal of the American Chemical Society, , vol. 111, # 16 p. 6354 - 6364
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
参考文献
Journal of the American Chemical Society, , vol. 111, # 16 p. 6354 - 6364
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Ikegami, Satoru; Uchiyama, Harumi; Hayama, Takashi; Katsuki, Tsutomu; Yamaguchi, Masaru
Tetrahedron, 1988 , vol. 44, # 17 p. 5333 - 5342
反应条件
1: aq. NaOH 2: (enzymatic racemate resolution) View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 88, p. 819 - 827
反应条件
1: aq. KOH / ethanol 2: (enzymatic racemate resolution) View Scheme
参考文献
Helvetica Chimica Acta, , vol. 59, p. 2181 - 2183
