(4S,5R)-(?)-顺-4,5-二苯基-2-噁唑烷酮合成路线 （共 25 条）
反应条件
sodium ethanolate in ethanol; toluene T=90 - 110°C; 7 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/92318 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
反应条件
sodium acetate; palladium diacetate in acetonitrile T=20°C; P=760 Torr; Electrolysis;
参考文献
Chiarotto, Isabella; Feroci, Marta
Tetrahedron Letters, 2001 , vol. 42, # 20 p. 3451 - 3453
反应条件
1: With N(Et)4(1+)*(2-pyrrolidone-anion) in acetonitrile T=20°C; Carboxylation; 1 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=20°C; Cyclization; Further stages.;
参考文献
Casadei, M. Antonietta; Feroci, Marta; Inesi, Achille; Rossi, Leucio; Sotgiu, Giovanni
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4759 - 4761
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Begis, Guillaume; Sheppard, Tom D.; Cladingboel, David E.; Motherwell, William B.; Tocher, Derek A.
Synthesis, 2005 , # 19 art. no. C06405SS, p. 3186 - 3188
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 6 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 20 p. 6536 - 6537
反应条件
1: in acetonitrile T=20°C; Acylation; 2 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=25°C; Cyclization; 10 h;
参考文献
Feroci, Marta; Inesi, Achille; Mucciante, Vittoria; Rossi, Leucio
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6059 - 6060
反应条件
ammonia; lithium; iron nitrate (III) T=-78°C; 0.5 h;
参考文献
Arnum, Susan D. Van; Carpenter, Barry K.; Parrish, David R.; MacIntrye, Archibald
Journal of Organic Chemistry, 2004 , vol. 69, # 24 p. 8533 - 8536
反应条件
methanesulfonic acid; methoxybenzene T=50°C; 1.5 h;
参考文献
Sugiyama, Shigeo; Morishita, Kenji; Chiba, Mariko; Ishii, Keitaro
Heterocycles, 2002 , vol. 57, # 4 p. 637 - 648
反应条件
1: (1R,2S)-(-)-2-Amino-1,2-diphenylethanol in acetonitrile T=20°C; Electrolysis; 2: carbon dioxide 1 h; 3: p-toluenesulfonyl chloride T=20°C;
参考文献
Tetrahedron Letters, , vol. 43, # 33 p. 5863 - 5865
反应条件
3,3-dimethyldioxirane in acetone
参考文献
Organic Letters, , vol. 10, # 4 p. 661 - 663
