3-氨基-2-喹噁啉甲腈 1,4-二氧化物合成路线 （共 12 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=0°C; 3 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/111442 A1, 2009 ;
Location in patent: Page/Page column 53.54 ;
WO 2009/111442 A1
反应条件
triethylamine in ethanol 4 h; Ambient temperature;
参考文献
Borah, Harsha Narayan; Boruah, Romesh Chandra; Sandhu, Jagir Singh
Heterocycles, 1984 , vol. 22, # 10 p. 2323 - 2325
反应条件
triethylamine in ethanol 4 h; Ambient temperature;
参考文献
Borah, Harsha Narayan; Boruah, Romesh Chandra; Sandhu, Jagir Singh
Heterocycles, 1984 , vol. 22, # 10 p. 2323 - 2325
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 3: toluene / 2 h / Heating 4: 75 percent / triethylamine / dimethylformamide / 24 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: toluene / 2 h / Heating 2: 75 percent / triethylamine / dimethylformamide / 24 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 2: toluene / 2 h / Heating 3: 75 percent / triethylamine / dimethylformamide / 24 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C 3: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 4: toluene / 2 h / Heating 5: 75 percent / triethylamine / dimethylformamide / 24 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h 2: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h 3: 90 percent / hydrazine hydrate / 1 h / Heating 4: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h 2: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h 3: 53 percent / dimethylsulfoxide / 0.17 h / Ambient temperature View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
sodium dithionite in methanol
T=50°C; 3 h;
参考文献
Monge, A.; Palop, J. A.; Castillo, J. C. Del; Caldero, J. M.; Roca, J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2745 - 2750
