3,5-二氯-4-羟基苯甲醛合成路线 （共 17 条）
反应条件
oxygen; [Co(O2CCH3)2]*4H2O; sodium hydroxide in ethylene glycol T=80°C; P=760.051 Torr; 8 h;
参考文献
Jiang, Jian-An; Chen, Cheng; Guo, Ying; Liao, Dao-Hua; Pan, Xian-Dao; Ji, Ya-Fei
Green Chemistry, 2014 , vol. 16, # 5 p. 2807 - 2814
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane 16 h; Ambient temperature;
参考文献
Becker, Hans-Dieter; Bjoerk, Anders; Adler, Erich
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1596 - 1600
反应条件
1: With acetic acid Duff Reaction; 3 h; Reflux; 2: With sulfuric acid; water T=100°C;
参考文献
MERCK PATENT GMBH; KADAM, Shahuraj Hanamantrao; PAKNIKAR, Shashikumar
Patent: WO2011/128018 A1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With gamma-aminopropyltriethoxysilane in acetonitrile 0.166667 h; 2: With N-chloro-succinimide in acetonitrile T=20°C;
参考文献
Ngi, Samuel Inack; Petrignet, Julien; Duwald, Romain; El Hilali, El Mostafa; Abarbri, Mohamed; Duchene, Alain; Thibonnet, Jerome
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 14-15 p. 2936 - 2941
反应条件
1: [2-(2,6-dichloro-4-iodo-phenoxymethoxy)-ethyl]-trimethylsilane With isopropylmagnesium chloride in tetrahydrofuran T=-20 - -10°C; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-10 - 20°C; 3: With hydrogenchloride; water in tetrahydrofuran T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/100026 A1, 2006 ;
Location in patent: Page/Page column 122 ;
WO 2006/100026 A1
反应条件
1: 21.3 percent / NaOH / H2O / 192 h / 70 °C 2: 15 percent / KF*2H2O, tetrabutylammonium chloride / 30 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 316, # 3 p. 193 - 201
反应条件
calcium hydroxide powder; sodium carbonate in water 2 h; Heating;
参考文献
Knuutinen, Juha S.; Kolehmainen, Erkki T.
Journal of Chemical & Engineering Data, 1983 , vol. 28, # 1 p. 139 - 141
反应条件
1: 4.6 g / LiAlH4 / tetrahydrofuran / 12 h / Heating 2: 4.4 g / DDQ / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 16 p. 5658 - 5661
反应条件
potassium fluoride; tetrabutyl-ammonium chloride 30 h; Heating;
参考文献
Archiv der Pharmazie, , vol. 316, # 3 p. 193 - 201
反应条件
potassium fluoride; tetrabutyl-ammonium chloride 30 h; Heating;
参考文献
Renger
Archiv der Pharmazie, 1983 , vol. 316, # 3 p. 193 - 201
