1: With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=40°C; 1 h; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20°C; 3 h;
参考文献
ZENTIVA, K.S.; RADL, Stanislav; STEFKO, Martin; CERNY, Josef
Patent: WO2014/59956 A1, 2014 ;
Location in patent: Page/Page column 12 ;
1: 2-(methanesulphonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 0.5 h; 2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride With water in tetrahydrofuran T=20°C; 4 h; 3: With sodium tris(acetoxy)borohydride in tetrahydrofuran
1: With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=30 - 35°C; 2 h; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20 - 25°C; 3 h; 3: With water; sodium hydroxide in tetrahydrofuran
