3-氯苯肼盐酸盐合成路线

2312-23-43-氯苯肼盐酸盐

15001-08-85-氨基-1-(3-氯苯基)-1H-吡唑-4-羧酸乙酯

参考文献

Eli Lilly and Company
Patent: US4775409 A1, 1988 ;

2312-23-43-氯苯肼盐酸盐+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

15001-08-85-氨基-1-(3-氯苯基)-1H-吡唑-4-羧酸乙酯

参考文献

Eli Lilly and Company
Patent: US4620865 A1, 1986 ;

42466-67-1(E)-2-氰基-3-乙氧基丙烯酸乙酯+

2312-23-43-氯苯肼盐酸盐

15001-08-85-氨基-1-(3-氯苯基)-1H-吡唑-4-羧酸乙酯

参考文献

BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
Location in patent: Paragraph 00321 ;
WO 2013/022818 A1

参考文献

Xiao, Fuhong; Liao, Yunfeng; Wu, Mingyue; Deng, Guo-Jun
Green Chemistry, 2012 , vol. 14, # 12 p. 3277 - 3280

2312-23-43-氯苯肼盐酸盐+

82874-96-22-(甲氧基亚胺)-4-氧代-戊酸乙酯

709654-29-5

参考文献

Lam, Patrick Y. S.; Clark, Charles G.; Li, Renhua; Pinto, Donald J. P.; Orwat, Michael J.; Galemmo, Robert A.; Fevig, John M.; Teleha, Christopher A.; Alexander, Richard S.; Smallwood, Angela M.; Rossi, Karen A.; Wright, Matthew R.; Bai, Stephen A.; He, Kan; Luettgen, Joseph M.; Wong, Pancras C.; Knabb, Robert M.; Wexler, Ruth R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4405 - 4418

2312-23-43-氯苯肼盐酸盐

65740-38-73-氨基-1-(3-氯苯基)吡唑

参考文献

Doria, G.; Passarotti, C.; Sala, R.; Magrini, R.; Sberze, P.; et al.
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 417 - 429

80030-73-5+

2312-23-43-氯苯肼盐酸盐

81016-50-41H-吡唑-3-羧酸,5-甲基-4-硝基-,2-(3-氯苯基)酰肼

参考文献

Baraldi, P. G.; Guarneri, M.; Moroder, F; Simoni, D.; Vicentini, C. B.
Synthesis, 1982 , # 1 p. 70 - 71

2312-23-43-氯苯肼盐酸盐

81016-56-04-氨基-5-甲基-1H-吡唑-3-羧酸2-(3-氯苯基)酰肼

参考文献

Baraldi, P. G.; Guarneri, M.; Moroder, F; Simoni, D.; Vicentini, C. B.
Synthesis, 1982 , # 1 p. 70 - 71

2312-23-43-氯苯肼盐酸盐

872675-03-1

参考文献

McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158

2312-23-43-氯苯肼盐酸盐

872675-04-2

参考文献

McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158