2-氨基-4-甲基苯甲酸合成路线 （共 49 条）
反应条件
1: 64 percent / Cu, N-ethylmorpholine / various solvent(s) / 5 h / 120 °C
2: ethyl polyphosphate
3: NaOH, H2O / ethanol
View Scheme
参考文献
Rewcastle, Gordon W.; Denny, William A
Synthetic Communications, 1987 , vol. 17, # 3 p. 309 - 318
反应条件
1: With hydrogenchloride; sodium nitrite
0.5 h;
2: With sodium azide; sodium acetate
0.25 h;
参考文献
Thomas, Andrew W
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1881 - 1884
反应条件
hydrogenchloride
Diazotization.Eintragen in eine aus Kupfer(II)-sulfat, Hydroxylamin-hydrochlorid und wss. Ammoniak hergestellte Loesung;
参考文献
Chardonnens; Wuermli
Helvetica Chimica Acta, 1946 , vol. 29, p. 922,924
反应条件
Reaktion ueber mehrere Stufen;
参考文献
Chardonnens; Wuermli
Helvetica Chimica Acta, 1946 , vol. 29, p. 922,924
反应条件
ammonium hydroxide; ammonia; copper(II) sulfate in water; toluene
参考文献
Warner-Lambert Company
Patent: US5486512 A1, 1996 ;
US 5486512 A
反应条件
1: With acetic acid in water
T=20°C; 0.5 h;
2: With sodium hydroxide in water
T=50°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/28904 A1, 2006 ;
Location in patent: Page/Page column 159 ;
WO 2006/028904 A1
参考文献
Chen, Zecheng; Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Santos, Osvaldo Dos; Santos, Efren Delos; Ayral-Kaloustian, Semiramis; Chen, Lei; Geng, Yi; Arndt, Kim T.; Lucas, Judy; Chaudhary, Inder; Mansour, Tarek S.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4980 - 4983
反应条件
1: aqueous hydrochloric acid
2: aqueous HCl
View Scheme
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
反应条件
1: aq. NaOH solution
2: phosphorus (V)-chloride; toluene; aluminium chloride / Behandeln des nach der Hydrolyse (wss. Salzsaeure) erhaltenen Reaktionsprodukts mit Schwefelsaeure
3: aqueous H2SO4; NaNO2 / Erwaermen der Reaktionsloesung auf 80grad
View Scheme
参考文献
Chardonnens; Wuermli
Helvetica Chimica Acta, 1946 , vol. 29, p. 922,924
