3-羟基-2-碘-6-甲基吡啶合成路线 （共 7 条）
反应条件
iodine; sodium hydrogencarbonate in tetrahydrofuran 24 h;
参考文献
Massa, Mark A.; Patt, William C.; Ahn, Kyunghye; Sisneros, Andre M.; Herman, Sarah B.; Doherty, Annette
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 16 p. 2117 - 2122
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C 2: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C 4: 5 h / Reflux 5: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C 6: manganese(IV) oxide / dichloromethane / 0 - 20 °C View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
反应条件
potassium carbonate in acetone T=45°C; 20 h;
参考文献
DECODE GENETICS EHF
Patent: US2009/136473 A1, 2009 ;
Location in patent: Page/Page column 58 ;
US 20090136473 A1
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride 3 h; Heating / reflux;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2006/24666 A1, 2006 ;
Location in patent: Page/Page column 49-50 ;
WO 2006/024666 A1
反应条件
iodine; sodium carbonate in water
T=20°C;
参考文献
Lin, Wenwei; Chen, Ling; Knochel, Paul
Tetrahedron, 2007 , vol. 63, # 13 p. 2787 - 2797
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=100°C; P=7500.75 Torr; 3 h;
参考文献
AstraZeneca AB
Patent: US2009/48269 A1, 2009 ;
Location in patent: Page/Page column 64 ;
US 20090048269 A1
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C
2: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
4: 5 h / Reflux
5: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
