4-甲氧基-2-硝基苯甲醛合成路线 （共 25 条）
反应条件
1: With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 4.5 h; Heating / reflux; 2: With Ag2CO3 in water; acetone T=20°C;
参考文献
NOVARTIS VACCINES and DIAGNOSTICS, INC.
Patent: WO2007/117607 A2, 2007 ;
Location in patent: Page/Page column 309-310 ;
反应条件
sulfuric acid; nitric acid T=0 - 20°C; 0.5 h; Inert atmosphere;
参考文献
Takrouri, Khuloud; Chen, Ting; Papadopoulos, Evangelos; Sahoo, Rupam; Kabha, Eihab; Chen, Han; Cantel, Sonia; Wagner, Gerhard; Halperin, Jose A.; Aktas, Bertal H.; Chorev, Michael
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 361 - 377
反应条件
1: With diisobutylaluminium hydride in diethyl ether; toluene T=0°C; 0.333333 h; 2: With silica gel in diethyl ether; toluene Further stages.;
参考文献
Gallou-Dagommer, Isabelle; Gastaud, Philippe; RajanBabu
Organic Letters, 2001 , vol. 3, # 13 p. 2053 - 2056
反应条件
Celite; water; pyridinium chlorochromate in dichloromethane T=20°C; 4.5 h;
参考文献
Siles, Rogelio; Ackley, J. Freeland; Hadimani, Mallinath B.; Hall, John J.; Mugabe, Benon E.; Guddneppanavar, Rajsekhar; Monk, Keith A.; Chapuis, Jean-Charles; Pettit, George R.; Chaplin, David J.; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M.; Pinney, Kevin G.
Journal of Natural Products, 2008 , vol. 71, # 3 p. 313 - 320
反应条件
tetra(n-butyl)ammonium dichromate(VI) in chloroform 0.166667 h; Heating;
参考文献
Katritzky, Alan R.; Xu, Yong-Jiang; Vakulenko, Anatoliy V.; Wilcox, Allan L.; Bley, Keith R.
Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 9100 - 9104
反应条件
1: With phenyllithium in tetrahydrofuran T=-90 - -70°C; 2 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=-90 - 0°C; 2 h; Further stages.;
参考文献
Shen, Bin; Loeffler, Dirk; Zeller, Klaus-Peter; Uebele, Michael; Reischl, Gerald; Machulla, Hans-Juergen
Journal of Fluorine Chemistry, 2007 , vol. 128, # 12 p. 1461 - 1468
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride; sodium nitrite in water 0.25 h; 2: formaldehyde oxime sodium salt With sodium acetate; copper(II) sulfate; sodium sulfite in water T=20°C; 2 h;
参考文献
Kataoka, Tadashi; Watanabe, Shin-Ichi; Mori, Eiji; Kadomoto, Ryoji; Tanimura, Susumu; Kohno, Michiaki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2397 - 2407
反应条件
trifluoromethylsulfonic anhydride; [EtNH3][NO3] T=0 - 20°C; 0.666667 h; Inert atmosphere;
参考文献
Aridoss, Gopalakrishnan; Laali, Kenneth K.
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8088 - 8094
反应条件
1: BH3 / tetrahydrofuran / 3 h / Heating 2: pyridinium dichromate; molecular sieves / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6412 - 6415
反应条件
1.1: c. hydrochloric acid / H2O / 0.33 h / Heating 1.2: sodium nitrite / H2O / 0.5 h 1.3: 78 percent / copper cyanide / H2O / 2 h / Heating 2.1: DIBAL / toluene; diethyl ether / 0.33 h / 0 °C 2.2: 99 percent / silica gel / toluene; diethyl ether View Scheme
参考文献
Organic Letters, , vol. 3, # 13 p. 2053 - 2056
