3-羟基-2,6-二甲基吡喃-4-酮合成路线 （共 6 条）
反应条件
water; chlorine 1) methanol, room temp., 1.5 h, 2) 140 deg C; Yield given. Multistep reaction;
参考文献
Pfizer Inc.
Patent: US4082717 A1, 1978 ;
反应条件
hydrogenchloride; zinc T=60°C; 24 h;
参考文献
Ellis, Beverley L.; Duhme, Anne K.; Hider, Robert C.; Hossain, M. Bilayet; Rizvi, Safia; Van Der Helm, Dick
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3659 - 3670
反应条件
selenium(IV) oxide in ethanol 4 h; Heating;
参考文献
Sato, Kikumasa; Inoue, Seiichi; Tanami, Tohru; Ohasi, Masao
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1015 - 1018
反应条件
1: 86 percent / aq. sodium hydroxide / 24 h / 25 °C 2: 53 percent / zinc, aq. hydrochloric acid / 24 h / 60 °C View Scheme
参考文献
Ellis, Beverley L.; Duhme, Anne K.; Hider, Robert C.; Hossain, M. Bilayet; Rizvi, Safia; Van Der Helm, Dick
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3659 - 3670
反应条件
1: 1.) zinc, 2.) aq. hydrochloric acid / 1.) water, 40 deg C, 2.) 60 deg C, 3 h 2: 86 percent / aq. sodium hydroxide / 24 h / 25 °C 3: 53 percent / zinc, aq. hydrochloric acid / 24 h / 60 °C View Scheme
参考文献
Ellis, Beverley L.; Duhme, Anne K.; Hider, Robert C.; Hossain, M. Bilayet; Rizvi, Safia; Van Der Helm, Dick
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3659 - 3670
反应条件
1: 1.) ozone, 2.) dimethyl sulphide / 1.) methanol, -50 deg C, 1 h, oxygen, 2.) -10 deg C, 1 h, room temperature, 1.5 h 2: 30 percent / selenium dioxide / aq. ethanol / 4 h / Heating View Scheme
参考文献
Sato, Kikumasa; Inoue, Seiichi; Tanami, Tohru; Ohasi, Masao
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1015 - 1018
