N-(4-甲氧基苯基)-2-硝基苯甲酰胺合成路线 （共 5 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=0°C; 1 h;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2008/94909 A2, 2008 ;
Location in patent: Page/Page column 91 ;
WO 2008/094909 A2
反应条件
1: ortho-nitrobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 4 h; 2: 4-methoxy-aniline With triethylamine in dichloromethane T=20°C; 18 h;
参考文献
DECODE CHEMISTRY, INC.
Patent: US2007/142434 A1, 2007 ;
Location in patent: Page/Page column 6-7; 9 ;
反应条件
potassium phosphate; copper(l) iodide; ethylenediamine in 1,4-dioxane Heating;
参考文献
Kang, Suk-Ku; Kim, Doo-Hwan; Park, Joung-Nam
Synlett, 2002 , # 3 p. 427 - 430
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 16 h;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2008/94909 A2, 2008 ;
Location in patent: Page/Page column 91 ;
WO 2008/094909 A2
反应条件
1,1'-bis-(diphenylphosphino)ferrocene in chlorobenzene
T=160°C; 24 h; Inert atmosphereSealed tube;
参考文献
Wang, Huamin; Cao, Xiangxiang; Xiao, Fuhong; Liu, Saiwen; Deng, Guo-Jun
Organic Letters, 2013 , vol. 15, # 18 p. 4900 - 4903
