4-[(1R,6R)-3-甲基-6-(1-甲基乙烯基)-2-环己烯-1-基]-5-戊基-1,3-苯二酚合成路线 （共 15 条）
反应条件
aluminum oxide; boron trifluoride diethyl etherate in dichloromethane
T=40 - 41°C; 0.00277778 h;
参考文献
Baek, Seung-Hwa; Srebnik, Morris; Mechoulam, Raphael
Tetrahedron Letters, 1985 , vol. 26, # 8 p. 1083 - 1086
反应条件
MoCl2(acetylacetonate)2; silver trifluoromethanesulfonate in dichloromethane
T=-20°C; 3 h;
参考文献
Malkov, Andrei V.; Kocovsky, Pavel
Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 8 p. 1257 - 1268
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: CuI
2: aq. HCl, Py
3: oxalic acid
View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
反应条件
1: boron trifluoride diethyl etherate; magnesium sulfate / dichloromethane / 1 h / -40 °C / Inert atmosphere
2: 2,6-dimethylpyridine / dichloromethane / 20 °C
3: dilithium tetrachlorocuprate / tetrahydrofuran / 3 h / 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: 2,6-dimethylpyridine / dichloromethane / 20 °C
2: dilithium tetrachlorocuprate / tetrahydrofuran / 3 h / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: dilithium tetrachlorocuprate / tetrahydrofuran / 3 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: hexane; toluene / 4.5 h / 40 °C
2: dihydrogen peroxide; sodium hydroxide / water; toluene
3: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 20 °C / Cooling with ice
4: boron tribromide / dichloromethane; 1,2-dichloro-ethane / 1.5 h / Reflux
5: boron trifluoride diethyl etherate; magnesium sulfate / dichloromethane / 1 h / -40 °C / Inert atmosphere
6: 2,6-dimethylpyridine / dichloromethane / 20 °C
7: dilithium tetrachlorocuprate / tetrahydrofuran / 3 h / 20 °C
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: boron tribromide / dichloromethane; 1,2-dichloro-ethane / 1.5 h / Reflux
2: boron trifluoride diethyl etherate; magnesium sulfate / dichloromethane / 1 h / -40 °C / Inert atmosphere
3: 2,6-dimethylpyridine / dichloromethane / 20 °C
4: dilithium tetrachlorocuprate / tetrahydrofuran / 3 h / 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Byard, Stephen J.; Carr, Steven A.; DeFaria, Jose F.; Filer, Crist N.; Herbert, John M.; Forcadac, Tatiana Jaramillo
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 180 - 184
反应条件
1: PBr3
2: CuI
3: aq. HCl, Py
4: oxalic acid
View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
