1-乙酰基-6-硝基吲哚啉合成路线 （共 8 条）
反应条件
triethylamine; acetyl chloride in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
PTC THERAPEUTICS, INC.; HWANG, Peter Seongwoo; TAKASUGI, James; REN, Hongyu; WILDE, Richard Gerald; TURPOFF, Anthony; AREFOLOV, Alexander; KARP, Gary Mitchell; CHEN, Guangming; CAMPBELL, Jeffrey Allen
Patent: WO2006/19831 A1, 2006 ;
Location in patent: Page/Page column 447 ;
参考文献
Okwakol, Jealux; Grivas, Spiros
Heterocycles, 2005 , vol. 65, # 8 p. 1939 - 1946
反应条件
1: 80 percent / HNO3; H2SO4 / 20 °C 2: 95 percent / 160 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 40, # 2 p. 167 - 172
反应条件
1: H2 / Pd/C 2: 1.) NaNO2 3: 86 percent View Scheme
参考文献
Yamada, Koji; Somei, Masanori
Heterocycles, 1998 , vol. 48, # 12 p. 2481 - 2484
反应条件
1: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C 2: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C 3: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C View Scheme
参考文献
Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290
反应条件
1: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C 2: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C 3: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C 4: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 10 p. 1277 - 1290
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1.4 h;
参考文献
Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290
反应条件
1: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C 2: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C View Scheme
参考文献
Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290
