1-溴-4-丙-2-烯基苯合成路线 （共 25 条）
反应条件
1: p-bromophenyl bromide With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=-5°C; 4.5 h; Inert atmosphere; 2: allyl bromide With copper (I) cyanide in tetrahydrofuran; hexane T=-5 - 20°C; 15.5 h; Inert atmosphere;
参考文献
Maegawa, Yoshifumi; Waki, Minoru; Umemoto, Akinari; Shimada, Toyoshi; Inagaki, Shinji
Tetrahedron, 2013 , vol. 69, # 26 p. 5312 - 5318
反应条件
1: 4-bromo-1-iodobenzene With (nBu)3MgLi in tetrahydrofuran; hexane T=-78°C; Metallation; 2: allyl bromide in tetrahydrofuran; hexane T=0°C; Alkylation; 0.5 h;
参考文献
Kitagawa, Kazuya; Inoue, Atsushi; Shinokubo, Hiroshi; Oshima, Koichiro
Angewandte Chemie - International Edition, 2000 , vol. 39, # 14 p. 2481 - 2483
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=20°C; 0.25 h;
参考文献
Bumagin, N. A.; Kasatkin, A. N.; Beletskaya, I. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1696 - 1703
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 8 p. 1858 - 1865
反应条件
triphenyl phosphite; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in 1,4-dioxane T=100°C; Suzuki-Miyaura coupling; 3 h;
参考文献
Kayaki, Yoshihito; Koda, Takashi; Ikariya, Takao
European Journal of Organic Chemistry, 2004 , # 24 p. 4989 - 4993
反应条件
Pd(NCOC2H4CO)(PPh3)2Br in toluene T=60°C; Stille cross-coupling;
参考文献
Crawforth, Catherine M.; Fairlamb, Ian J. S.; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 461 - 465
反应条件
xanthone powder in acetonitrile T=20°C; Photolysis;
参考文献
Milanesi, Silvia; Fagnoni, Maurizio; Albini, Angeld
Journal of Organic Chemistry, 2005 , vol. 70, # 2 p. 603 - 610
反应条件
cesium fluoride; bis(dibenzylideneacetone)-palladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane T=80 - 100°C;
参考文献
Young, Andrew J.; White, M. Christina
Journal of the American Chemical Society, 2008 , vol. 130, # 43 p. 14090 - 14091
反应条件
in meta-dibromobenzene
参考文献
Hughes Aircraft Company
Patent: EP314778 B1, 1991 ;
反应条件
1: para-bromotoluene With iodine; magnesium in diethyl ether T=20°C; 3 h; Inert atmosphereCooling with iceReflux; 2: allyl bromide With 2C19H16*2Cl(1-)*Ni(2+) in diethyl ether T=20°C; 50 h; Inert atmosphereReflux;
参考文献
Zhu, Lin; Liu, Huashi; Guan, Ruifang; Zhou, Chuanjian
Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8775 - 8779
反应条件
tert.-butylnitrite in acetonitrile T=30°C; 1.33 h;
参考文献
Ek, Fredrik; Axelsson, Oskar; Wistrand, Lars-Goeran; Frejd, Torbjoern
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6376 - 6381
