甲基 7-甲氧基苯并[d][1,3]二氧代-5-羧酸合成路线 （共 32 条）
反应条件
1: 98 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.5 h 2: 91 percent / PCC, NaOAc / CH2Cl2 / 2 h 3: 1) n-BuLi / 1) THF, -50 deg C to RT, 20 min, 2) THF, RT, 30 min View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 65, # 10 p. 2390 - 2396
反应条件
bromine; acetic anhydride T=12 - 15°C; 2 h;
参考文献
Helvetica Chimica Acta, , vol. 86, # 6 p. 2239 - 2246
反应条件
1: 92 percent / Br2; Ac2O / 2 h / 12 - 15 °C 2: 39.8 percent / Cu / dimethylformamide / 4 h / Heating View Scheme
参考文献
Chang, Junbiao; Chen, Rongfeng; Guo, Ruiyun; Dong, Chunhong; Zhao, Kang
Helvetica Chimica Acta, 2003 , vol. 86, # 6 p. 2239 - 2246
反应条件
1: 41.0 g / LiALH4 / tetrahydrofuran / 2 h / Heating 2: 26.0 g / Pyridinium dichlorochromate / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 58, # 1 p. 346 - 351
反应条件
1: 62 percent / Br2; AcOH / 2 h / 20 °C 2: 90 percent / aq. KOH / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2131 - 2136
反应条件
1: 77 percent / HNO3 / 2 h / 0 - 5 °C
2: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Blair; Newbold
Journal of the Chemical Society, 1954 , p. 1836,1838
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
0.5 h;
参考文献
Pettit; Singh
Canadian Journal of Chemistry, 1987 , vol. 65, # 10 p. 2390 - 2396
反应条件
in ether-tetrahydrofuran
参考文献
ARIZONA BOARD OF REGENTS
Patent: EP276051 B1, 1991 ;
反应条件
1.1: 77 percent / HNO3 / 2 h / 0 - 5 °C
2.1: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
3.1: NaNO2; aq. HBr / 0 - 5 °C
3.2: 69 percent / CuBr; aq. HBr
View Scheme
参考文献
Chang, Junbiao; Chen, Rongfeng; Guo, Ruiyun; Dong, Chunhong; Zhao, Kang
Helvetica Chimica Acta, 2003 , vol. 86, # 6 p. 2239 - 2246
反应条件
1.1: 77 percent / HNO3 / 2 h / 0 - 5 °C
2.1: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
3.1: NaNO2; aq. HBr / 0 - 5 °C
3.2: 69 percent / CuBr; aq. HBr
4.1: 81 percent / aq. KOH / 5 h / Heating
View Scheme
参考文献
Chang, Junbiao; Guo, Xiaohe; Cheng, Senxiang; Guo, Ruiyun; Chen, Rongfeng; Zhao, Kang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2131 - 2136
