甲基 7-甲氧基苯并[d][1,3]二氧代-5-羧酸合成路线 （共 32 条）
反应条件
cesium fluoride in N,N-dimethyl-formamide 2 h; Heating;
参考文献
ARIZONA BOARD OF REGENTS
Patent: EP276051 B1, 1991 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=120°C;
参考文献
Takaoka, Shigeki; Takaoka, Noriko; Minoshima, Yuka; Huang, Jian-Mei; Kubo, Miwa; Harada, Kenichi; Hioki, Hideaki; Fukuyama, Yoshiyasu
Tetrahedron, 2009 , vol. 65, # 40 p. 8354 - 8361
反应条件
potassium carbonate in acetone T=80°C; 4 h; Heating / reflux;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 88 ;
反应条件
1: methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate With potassium carbonate in dimethyl sulfoxide T=20°C; 0.5 h; 2: methyl iodide in dimethyl sulfoxide 44 h;
参考文献
PAIN THERAPEUTICS, INC.
Patent: WO2010/51374 A1, 2010 ;
Location in patent: Page/Page column 124 ;
反应条件
potassium carbonate in ethyl acetate; acetone
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
potassium carbonate in dichloromethane; N,N-dimethyl-formamide T=105°C; 6 h;
参考文献
Wu, Gang; Guo, Huan-Fang; Gao, Kun; Liu, Yi-Nan; Bastow, Kenneth F.; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Xie, Lan
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5272 - 5276
反应条件
1: methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate With sodium hydroxide in ethanol T=0 - 20°C; Inert atmosphere; 2: dimethyl sulfate in ethanol 5 h; Inert atmosphereReflux;
参考文献
Sreedhar, Eppakayala; Sateesh Chandra Kumar; Venkateswar Reddy; Robinson; Suresh Babu; Madhusudana Rao; Srinivas
Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 440 - 448
反应条件
potassium carbonate in N-methyl-acetamide; water
反应条件
1: NaOH; Na2B4O7*10H2O / H2O / 20 °C 2: 10.4 g / K2CO2 / dimethylformamide / 4 h / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 340, # 5 p. 244 - 250
反应条件
1: 100 percent / sulfuric acid / 6 h / Heating 2: 98.5 percent / Amberlyst 15E / benzene / 18 h / Heating 3: potassium carbonate / dimethylformamide / 12 h / 70 °C 4: hydrochloric acid / methanol; H2O / 2 h / 20 °C 5: 85 percent / potassium fluoride / dimethylformamide / 110 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 7 p. 1909 - 1918
