5-乙酰氨基-2-溴-苯甲酸合成路线 （共 10 条）
反应条件
sodium hydroxide in water T=20°C; Cooling with ice;
参考文献
Santen Pharmaceutical Co., Ltd.; Kudou, Kazuhiro; Yamamoto, Noriyoshi; Ban, Masakazu; Ohno, Atsushi
Patent: US2013/310576 A1, 2013 ;
Location in patent: Paragraph 0155 ;
反应条件
pyridine; hydrogenchloride; acetic anhydride in ethanol; ethyl acetate
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6506769 B2, 2003 ;
US 6506769 B2
反应条件
permanganate(VII) ion; magnesium sulfate
参考文献
Chemische Berichte, , vol. 57, p. 2086
反应条件
1: acetic acid; bromine 2: aqueous potassium permanganate; magnesium sulfate View Scheme
参考文献
Helvetica Chimica Acta, , vol. 27, p. 888,889
参考文献
Chemische Berichte, , vol. 57, p. 2086
反应条件
1: tin; concentrated hydrochloric acid 2: glacial acetic acid View Scheme
参考文献
Chemische Berichte, , vol. 57, p. 2086
参考文献
Chemische Berichte, , vol. 57, p. 2086
反应条件
1: With acetyl chloride T=0 - 55°C; 3.5 h; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
ORION CORPORATION
Patent: WO2007/99200 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
WO 2007/099200 A1
反应条件
nitric acid T=0 - 35°C; 4 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2098513 A1, 2009 ;
Location in patent: Page/Page column 45 ;
EP 2098513 A1
反应条件
nitric acid in tetrahydrofuran; methanol; hexane; ethyl acetate
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6506769 B2, 2003 ;
US 6506769 B2
