甘氨酰-L-丙氨酰-L-亮氨酸合成路线 （共 9 条）
反应条件
1: diethyl phosphorocyanidate, TEA / dimethylformamide / 1.) 0 deg C; 2.) r.t. 2: H2 / 5percent Pd on charcoal / methanol / 10 h / Ambient temperature 3: diethyl phosphorocyanidate, TEA / dimethylformamide / 1.) 0 deg C; 2.) r.t. 4: TFA / 1 h / Ambient temperature View Scheme
参考文献
Ikota, Nobuo; Shioiri, Takayuki; Yamada, Shun-Ichi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3064 - 3069
反应条件
1: H2 / 5percent Pd on charcoal / methanol / 10 h / Ambient temperature 2: diethyl phosphorocyanidate, TEA / dimethylformamide / 1.) 0 deg C; 2.) r.t. 3: TFA / 1 h / Ambient temperature View Scheme
参考文献
Ikota, Nobuo; Shioiri, Takayuki; Yamada, Shun-Ichi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3064 - 3069
反应条件
1: diethyl phosphorocyanidate, TEA / dimethylformamide / 1.) 0 deg C; 2.) r.t. 2: TFA / 1 h / Ambient temperature View Scheme
参考文献
Ikota, Nobuo; Shioiri, Takayuki; Yamada, Shun-Ichi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3064 - 3069
反应条件
trifluoroacetic acid 1 h; Ambient temperature;
参考文献
Ikota, Nobuo; Shioiri, Takayuki; Yamada, Shun-Ichi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3064 - 3069
反应条件
5-hydrido-2,3,7,8-benzo-1,4,6,9-tetraoxa-5-phosphaspiro(4,4)non-2,7-diene; 1-hydroxy-pyrrolidine-2,5-dione; diethylaminomethylpolystyrene; hydrogen; palladium 1.) THF, 40 deg C, 96 h, 2.) AcOH; Yield given. Multistep reaction;
参考文献
Cadogan, J. I. G.; Gosney, Ian; Randles, David; Yaslak, Salih; Ambler, Richard P.
Journal of the Chemical Society, Chemical Communications, 1982 , # 5 p. 298 - 299
反应条件
1-hydroxy-pyrrolidine-2,5-dione; hydrogen; dicyclohexyl-carbodiimide; palladium 1.) THF, 5 deg C; 2.) THF, water, RT; investigation of racemization; Product distribution;
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418
参考文献
Ikota, Nobuo; Shioiri, Takayuki; Yamada, Shun-Ichi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3064 - 3069
反应条件
anschliessende Hydrierung an Platin und nachfolgendes Erwaermen;
参考文献
Holley; Holley
Journal of the American Chemical Society, 1952 , vol. 74, p. 1110
反应条件
anschliessende Hydrierung an Platin und nachfolgendes Erwaermen;
参考文献
Holley; Holley
Journal of the American Chemical Society, 1952 , vol. 74, p. 1110
