(S)-1-N-Boc-2-吡咯烷甲腈合成路线 （共 13 条）
反应条件
triethylamine; trifluoroacetic anhydride in dichloromethane T=0 - 20°C; 10 h; Inert atmosphere;
参考文献
Wang, Ziwen; Wei, Peng; Xizhi, Xu; Liu, Yuxiu; Wang, Lizhong; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 35 p. 8544 - 8551
反应条件
1: With triethylamine; isobutyl chloroformate in dichloromethane T=-25°C; 0.75 h; 2: With ammonia in methanol; dichloromethane T=20°C; 16 h; 3: With triethylamine; trifluoroacetic anhydride in tetrahydrofuran
参考文献
University of Virginia Patent Foundation
Patent: US2012/214858 A1, 2012 ;
Location in patent: Page/Page column 27-28 ;
US 20120214858 A1
反应条件
pyridine in ethyl acetate; N,N-dimethyl-formamide; acetonitrile
参考文献
Datta, Usa
Patent: US2002/151535 A1, 2002 ;
反应条件
in N,N-dimethyl-formamide T=0°C; 1 h;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION; SANTOS, Webster, L.; LYNCH, Kevin, R.; MACDONALD, Timothy, L.; KENNEDY, Andrew; KHAREL, Yugesh; RAJE, Mithun, Rajendra; HOUCK, Joseph
Patent: WO2013/119946 A1, 2013 ;
Location in patent: Paragraph 0530 ;
反应条件
1: With sodium diisobutyl-tert-butoxyaluminium hydride in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; 2: With ammonium hydroxide; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;
参考文献
Miyagi, Kotaro; Moriyama, Katsuhiko; Togo, Hideo
European Journal of Organic Chemistry, 2013 , # 26 p. 5886 - 5892
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 2.2: 6 h / 20 °C 3.1: 2,4,6-trimethyl-pyridine; 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 2.2: 6 h / 20 °C 3.1: 2,4,6-trimethyl-pyridine; 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
反应条件
1: 2: With trifluoroacetic anhydride
参考文献
Letters in Organic Chemistry, , vol. 10, # 3 p. 159 - 163
反应条件
1.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 1.2: 6 h / 20 °C 2.1: 2,4,6-trimethyl-pyridine; 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 2.2: 6 h / 20 °C 3.1: 2,4,6-trimethyl-pyridine; 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
