1: 1.) Et3N / 1) CH3CN, rt, 30 min; 2) CH3CN, rt, 24 h 2: 45 percent / TiCl3, NH4OAc / tetrahydrofuran; H2O / 2 h / Ambient temperature; pH 5.1 3: 81 percent / LiOH / tetrahydrofuran; H2O / 6 h / 50 °C 4: 1.) Et3N, 2,4,6-trichlorobenzoyl chloride, 2.) DMAP / 1) THF, rt, 6 h; 2) toluene, reflux, 6 h View Scheme