5-氨基-2-甲氧基苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: 3-amino-6-hydroxy-benzoic acid methyl ester With potassium tert-butylate in dimethyl sulfoxide T=20°C; 2 h; 2: dimethyl sulfate in dimethyl sulfoxide 0.0833333 h;
参考文献
Desreumaux, Pierre; Bellinvia, Salvatore; Chavatte, Philippe; Baroni, Sergio
Patent: US2011/39808 A1, 2011 ;
Location in patent: Page/Page column 50 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=1064.07 Torr; 5 h;
参考文献
Morgentin, Remy; Pasquet, Georges; Boutron, Pascal; Jung, Frederic; Lamorlette, Maryannick; Maudet, Mickael; Ple, Patrick
Tetrahedron, 2008 , vol. 64, # 12 p. 2772 - 2782
反应条件
1: With pyridine; trifluorormethanesulfonic acid; tetra-n-butylammonium tetrafluoroborate in acetonitrile T=25°C; Electrochemical reaction; 2: With piperidine in acetonitrile T=80°C; 12 h; Electrochemical reaction; Overall yield = 92 percent;
参考文献
Journal of the American Chemical Society, , vol. 135, # 13 p. 5000 - 5003
反应条件
1: NaH / dimethylformamide 2: H2 / Pd/C / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 916 - 920
反应条件
trifluoroacetic acid
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4094 - 4098
反应条件
1.1: sulfuric acid / Reflux 1.2: pH 7 2.1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C 2.2: 0.08 h View Scheme
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 1.2: 80 °C 2.1: palladium 10 on activated carbon; hydrogen / methanol / 3620.13 - 4137.29 Torr View Scheme
反应条件
1.1: methanol / 15 h / |Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 2.2: 80 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol / 3620.13 - 4137.29 Torr View Scheme
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 7 h;
参考文献
Hirashima, Shintaro; Oka, Takahiro; Ikegashira, Kazutaka; Noji, Satoru; Yamanaka, Hiroshi; Hara, Yoshinori; Goto, Hiroyuki; Mizojiri, Ryo; Niwa, Yasushi; Noguchi, Toru; Ando, Izuru; Ikeda, Satoru; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3181 - 3186
