4-溴-2,3-二甲基苯酚合成路线 （共 5 条）
反应条件
tetra-n-butylammonium tribromide in methanol; dichloromethane 0.5 h; Ambient temperaturereagent 1.0 equivalent;
参考文献
Bougdid, Lahoussine; Heynderickx, Arnault; Delbaere, Stephanie; Moustrou, Corinne
Tetrahedron, 2007 , vol. 63, # 34 p. 8242 - 8249
反应条件
1: aqueous HBr; acetic acid 2: glacial acetic acid; bromine / 0 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 319,321
反应条件
potassium carbonate in acetone T=70°C; 6 h;
参考文献
Takeuchi, Makoto; Kurahashi, Takuya; Matsubara, Seijiro
Chemistry Letters, 2012 , vol. 41, # 12 p. 1566 - 1568
参考文献
Baliah,V.; Uma,M.
Recueil des Travaux Chimiques des Pays-Bas, 1961 , vol. 80, p. 139 - 148
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.83 h / 0 - 23 °C / Inert atmosphere
1.2: 2.17 h / 23 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.5 h / 23 °C / Inert atmosphere
3.1: sulfuric acid / 13 h / Inert atmosphere; Reflux
View Scheme
参考文献
Fujii, Seiko; Chang, Stephanie Y.; Burke, Martin D.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 34 p. 7862 - 7864
