2-氟-5-(羟基甲基)苯甲腈合成路线 （共 4 条）
反应条件
1: With sodium tetrahydroborate in ethanol T=0 - 20°C; 1 h; 2: With hydrogenchloride; water in ethanol
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA SAN DIEGO, INC.
Patent: WO2007/75847 A2, 2007 ;
Location in patent: Page/Page column 99-101 ;
WO 2007/075847 A2
反应条件
1: 85 percent / N-methylpyrrolidinone / 24 h / Heating 2: 96 percent / NaBH4 / methanol / 0.67 h / 0 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 32, # 1 p. 88 - 91
反应条件
1: With sodium hydroxide in methanol; water T=60°C; 9 h; 2: With hydrogenchloride in water pH=3;
参考文献
Kudos Pharmaceuticals Ltd.
Patent: US2006/135770 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;
US 20060135770 A1
反应条件
N-bromosuccinmide; triphenylphosphine in dichloromethane T=0 - 20°C; Substitution;
参考文献
Cain, Gary A.
Organic Preparations and Procedures International, 2000 , vol. 32, # 1 p. 88 - 91
