4,4-二甲基-2-环戊烯-1-酮合成路线 （共 40 条）
反应条件
multistep synthesis; other α,β unsaturated ketones;
参考文献
Liu, Hsing-Jang; Zhu, Bing-Yan
Canadian Journal of Chemistry, 1991 , vol. 69, # 12 p. 2008 - 2013
反应条件
1: 65 percent / ethanol; acetic acid; H2O / 3 h / 45 - 50 °C
2: 70 percent / H2SO4 / H2O; dioxane / 12 h / Heating
View Scheme
参考文献
Schank, Kurt; Glock, Rebecca; Lick, Carlo
Helvetica Chimica Acta, 2005 , vol. 88, # 12 p. 3174 - 3199
反应条件
1: LiAlH4
2: aq. HBr, H2SO4
3: quinoline
4: H2 / PtO2 / acetic acid / 2280 Torr
View Scheme
参考文献
Rouse,S.; Tyler,W.E.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3525 - 3527
反应条件
lithium aluminium tetrahydride in diethyl ether
22 h; Heating;
参考文献
Holder, Richard W.; Daub, John P.; Baker, Wesley E.; Gilbert, Raymond H; Graf, Norman A.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1445 - 1451
反应条件
1: 91 percent / H2 / palladium on carbon / petroleum ether / 2.5 h / 2844.3 Torr / Ambient temperature
2: 76 percent / NaH / diethyl ether / Ambient temperature
View Scheme
参考文献
Paquette,L.A.; Leone-Bay,A.
Journal of the American Chemical Society, 1983 , vol. 105, p. 7352
反应条件
Wilkinson's catalyst in toluene
T=50°C; 3 h;
参考文献
Bode, Heinrich E.; Gregory Sowell; Daniel Little
Tetrahedron Letters, 1990 , vol. 31, # 18 p. 2525 - 2528
反应条件
1: 91 percent / H2 / palladium on carbon / petroleum ether / 2.5 h / 2844.3 Torr / Ambient temperature
2: 76 percent / NaH / diethyl ether / Ambient temperature
3: 78 percent / p-TsOH / benzene / Heating
View Scheme
参考文献
Paquette,L.A.; Leone-Bay,A.
Journal of the American Chemical Society, 1983 , vol. 105, p. 7352
反应条件
sodium hydride in diethyl ether
参考文献
Stevens; Cherpeck; Harrison; Lai; Lapalme
Journal of the American Chemical Society, 1976 , vol. 98, # 20 p. 6317 - 6321
反应条件
1: NaH / diethyl ether
2: (i) NaOMe, FClO3, MeOH, (ii) KOAc
View Scheme
参考文献
Thi,G.V.; Margaretha,P.
Helvetica Chimica Acta, 1976 , vol. 59, p. 2236 - 2243
反应条件
1: 79 percent / LiAlH4 / diethyl ether / 22 h / Heating
2: 48 aq. HBr, conc. sulfuric acid / 48 h / 25 °C
3: 83 percent / quninoline / 150 - 195 °C
View Scheme
参考文献
Rouse,S.; Tyler,W.E.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3525 - 3527
