4-(2-氧代丙基)苯甲酸甲酯合成路线 （共 12 条）
反应条件
in toluene
T=200°C; 16 h; Inert atmosphere;
参考文献
Lee, Jennifer J.; Kraus, George A.
Tetrahedron Letters, 2013 , vol. 54, # 19 p. 2366 - 2368
反应条件
NiBr2bipy; tetra-n-butylammonium tetrafluoroborate in N,N-dimethyl-formamide
T=70°C; i = 250 mA, nickel-sponge cathode;
参考文献
Durandetti, Muriel; Nedelec, Jean-Yves; Perichon, Jacques
Journal of Organic Chemistry, 1996 , vol. 61, # 5 p. 1748 - 1755
反应条件
Dess-Martin periodane in dichloromethane
T=20°C; 0.5 h;
参考文献
Ohno, Hiroaki; Okumura, Mitsuaki; Maeda, Shin-Ichiro; Iwasaki, Hiroki; Wakayama, Ryutaro; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7722 - 7732
反应条件
hydrogenchloride; sodium hydrogencarbonate in methanol; water
参考文献
Beecham Group Limited
Patent: US4478849 A1, 1984 ;
反应条件
1: With palladium diacetate; p-benozquinone in acetic acid; dimethyl sulfoxide
T=60°C; Heck Reaction; 12 h;
2: With hydrazine hydrate
Inert atmosphere;
参考文献
Meng, Lingkui; Liu, Chao; Zhang, Wei; Zhou, Chao; Lei, Aiwen
Chemical Communications, 2014 , vol. 50, # 9 p. 1110 - 1112
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; caesium carbonate
T=90°C; 12 h; Inert atmosphereSchlenk techniqueSealed tube;
参考文献
Li, Pengbin; Lue, Bo; Fu, Chunling; Ma, Shengming
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 7 p. 1255 - 1259
反应条件
1: 56 percent / tetrahydrofuran / 1 h / -40 °C
2: 36 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Ohno, Hiroaki; Okumura, Mitsuaki; Maeda, Shin-Ichiro; Iwasaki, Hiroki; Wakayama, Ryutaro; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7722 - 7732
反应条件
1: H2SO4 / tetrahydrofuran; H2O / 4 h / Heating
2: 56 percent / tetrahydrofuran / 1 h / -40 °C
3: 36 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Ohno, Hiroaki; Okumura, Mitsuaki; Maeda, Shin-Ichiro; Iwasaki, Hiroki; Wakayama, Ryutaro; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7722 - 7732
反应条件
1.1: MeONa / methanol / 0.17 h / 20 °C
1.2: 76 percent / toluene / 12 h / Heating
2.1: H2SO4 / tetrahydrofuran; H2O / 4 h / Heating
3.1: 56 percent / tetrahydrofuran / 1 h / -40 °C
4.1: 36 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Ohno, Hiroaki; Okumura, Mitsuaki; Maeda, Shin-Ichiro; Iwasaki, Hiroki; Wakayama, Ryutaro; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7722 - 7732
反应条件
water; copper dichloride; palladium dichloride in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Shabat, Doron; Sinha, Subhash; Reymond, Jean-Louis; Keinan, Ehud
Angewandte Chemie, 1996 , vol. 108, # 22 p. 2800 - 2802
