4-氯-2-羟基苯甲酸甲酯合成路线 （共 19 条）
反应条件
sulfuric acid in methanol
参考文献
Erbamont Inc.
Patent: EP234872 B1, 1991 ;
反应条件
thionyl chloride 3 h; Reflux;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 90-91 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 42-43 ;
反应条件
chlorine; iodine T=70°C; 2.5 h;
参考文献
Simonov, V. D.; Ivanov, V. I.; Galeeva, A. B.; Popova, N. F.
J. Appl. Chem. USSR (Engl. Transl.), 1981 , vol. 54, # 4 p. 930 - 932,771 - 772
反应条件
Phellinus ribis Karst var. ribis (NCWRF-FPRL 42) T=20°C;
参考文献
Organic and Biomolecular Chemistry, , vol. 6, # 7 p. 1251 - 1259
反应条件
1: 96.6 percent / sulfuric acid / 6 h / 120 °C 2: 96 percent / Cl2(g) / iodine / 2.5 h / 70 °C View Scheme
参考文献
J. Appl. Chem. USSR (Engl. Transl.), , vol. 54, # 4 p. 930 - 932,771 - 772
反应条件
triethylamine in dichloromethane T=-78 - 20°C;
参考文献
Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 334 - 343
反应条件
1: NH2NH2 / H2O / 20 °C 2: NaNO2; aq. AcOH / 0 °C 3: Et3N / diethyl ether / 20 °C 4: toluene / 60 - 90 °C 5: 0 °C 6: KOH View Scheme
参考文献
Jolivalt; Neuville; Boyer; Kerhoas; Mougin
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 14 p. 5046 - 5054
反应条件
1: methyl 4-chloro-2-hydroxybenzoate With potassium hydroxide in methanol T=20°C; 1 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran 48 h; Inert atmosphere;
参考文献
Gensini, Martina; Altamura, Maria; Dimoulas, Tula; Fedi, Valentina; Giannotti, Danilo; Giuliani, Sandro; Guidi, Antonio; Harmat, Nicholas J. S.; Meini, Stefania; Nannicini, Rossano; Pasqui, Franco; Tramontana, Manuela; Triolo, Antonio; Maggi, Carlo Alberto
ChemMedChem, 2010 , vol. 5, # 1 p. 65 - 78
反应条件
1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 20 °C / Cooling with ice; Inert atmosphere 1.2: 0.5 h / Reflux 2.1: thionyl chloride / 1,4-dioxane; tetrahydrofuran / 30 °C / Inert atmosphere 2.2: 30 °C 2.3: pH 2 View Scheme
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
