5-溴-2-甲基-2-戊烯合成路线 （共 93 条）
参考文献
Biernacki,W.; Sobotka,W.
Roczniki Chemii, 1976 , vol. 50, p. 1323 - 1327
反应条件
ethylenediamine in dimethyl sulfoxide
1 h; Ambient temperature;
参考文献
Jacobi, Peter A.; Kaczmarek, Colleen S.R.; Udodong, Uko E.
Tetrahedron, 1987 , vol. 43, # 23 p. 5475 - 5488
参考文献
Gamboni et al.
Helvetica Chimica Acta, 1954 , vol. 37, p. 964,970
反应条件
sodium iodide in acetone
T=20°C; 20 h;
参考文献
Vickers, Troy D.; Keay, Brian A.
Synlett, 2003 , # 9 SPEC. ISS. p. 1349 - 1351
反应条件
naphthalene; lithium in tetrahydrofuran
T=-78°C; 3 h; Inert atmosphere;
参考文献
Gonzalez-Lopez, Susana; Yus, Miguel; Ramon, Diego J.
Tetrahedron Asymmetry, 2012 , vol. 23, # 8 p. 611 - 615
反应条件
1.1: magnesium; ethylene dibromide / diethyl ether / 2 h / 0 °C / |Inert atmosphere
1.2: 18 h / 0 - 20 °C / |Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 16 h / -78 - 20 °C
View Scheme
参考文献
Gesmundo, Nathan J.; Nicewicz, David A.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 1272 - 1281
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1633817/
2: aq. HBr / 0.5 h / 10 - 15 °C
3: KOAc / acetic acid / 15 h / Heating
View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
反应条件
1: 88.3 percent / dimethylsulfoxide / Ambient temperature
2: 94.5 percent / KOH / ethane-1,2-diol; H2O / 7.5 h / Heating
View Scheme
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1633817/
2: aq. HBr / 0.5 h / 10 - 15 °C
3: (i) Mg, Et2O, (ii) /BRN= 1633817/, Et2O
4: aq. HBr / 0.75 h / Ambient temperature
5: dimethylformamide / 24 h / 70 °C
View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 1072 - 1079
反应条件
2: 64 percent / pyridinium p-toluenesulfonate (PPTS) / ethanol / 60 °C
View Scheme
参考文献
Poulter, C. Dale; Wiggins, Paul L.; Plummer, Thomas L.
Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1532 - 1538
