(3,4-二甲氧基苯基)(3,4,5-三甲氧基苯基)-甲酮合成路线 （共 11 条）
反应条件
potassium carbonate in acetone 2 h; Inert atmosphereReflux;
参考文献
Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054
反应条件
tin(ll) chloride in dichloromethane 6 h; Ambient temperature;
参考文献
Rigby, James H.; Kotnis, Atul; Kramer, James
Journal of Organic Chemistry, 1990 , vol. 55, # 17 p. 5078 - 5088
反应条件
1: SOCl2 / CHCl3 / Heating 2: toluene / Ambient temperature 3: 1.) t-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h View Scheme
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
1: toluene / Ambient temperature 2: 1.) t-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h View Scheme
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
1: water; sodium acetate / methanol / 2 h / Reflux 2: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux View Scheme
参考文献
Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054
反应条件
1: methanesulfonic acid; phosphorous pentoxide / 4 h / 60 °C / Inert atmosphere 2: water; sodium acetate / methanol / 2 h / Reflux 3: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux View Scheme
参考文献
Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054
反应条件
1: 8 h / 135 °C / Inert atmosphere 2: methanesulfonic acid; phosphorous pentoxide / 4 h / 60 °C / Inert atmosphere 3: water; sodium acetate / methanol / 2 h / Reflux 4: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux View Scheme
参考文献
Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054
反应条件
tert.-butyl lithium 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
参考文献
Klemm; Bower
Journal of Organic Chemistry, 1958 , vol. 23, p. 344,347
反应条件
1: PCl5 2: CS2; AlCl3 View Scheme
参考文献
v. Kostanecki; Tambor
Chemische Berichte, 1906 , vol. 39, p. 4023
