2-硝基-4-(三氟甲氧基)苯胺合成路线 （共 9 条）
反应条件
1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 3: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
sodium hydroxide in methanol T=20 - 30°C; 1 h; Large scale reaction;
参考文献
Maligres, Peter E.; Humphrey, Guy R.; Marcoux, Jean-Francois; Hillier, Michael C.; Zhao, Dalian; Krska, Shane; Grabowski, Edward J.J.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 525 - 534
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: With sodium nitrite in water; acetic acid T=-10 - -5°C; 2: With sodium iodide in water; acetic acid T=0 - 15°C; 0.833333 h;
参考文献
Organic Process Research and Development, , vol. 13, # 3 p. 525 - 534
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol T=70 - 80°C; 0.5 h; 2: With sodium hydroxide in ethanol T=0 - 5°C; pH=11 - 12;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/50148 A2, 2006 ;
Location in patent: Page/Page column 38 ;
反应条件
1: With palladium on activated charcoal; hydrogen in methanol T=20 - 25°C; 1 h; 2: With hydrogenchloride; acetic acid; sodium nitrite in water T=0 - 20°C; 2 h;
参考文献
AVENTIS AGRICULTURE; MERIAL LIMITED; Soll, Mark David; Le Hir de Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms
Patent: US2014/80862 A1, 2014 ;
Location in patent: Paragraph 0490 ;
反应条件
1: 2-nitro-4-(trifluoromethoxy)aniline With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.166667 h; Cooling with ice; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=20°C; 1 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; TAKAHASHI, Masaki; IWAKOSHI, Mitsuhiko; IKEGAMI, Hiroshi
Patent: WO2010/125985 A1, 2010 ;
Location in patent: Page/Page column 247-248 ;
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile
T=20°C; 1 h;
参考文献
Kuntz, Kevin; Emmitte, Kyle Allen; Rheault, Tara Renae; Smith, Stephon; Hornberger, Keith; Dickson, Hamilton; Cheung, Mui
Patent: US2008/300247 A1, 2008 ;
Location in patent: Page/Page column 50 ;
反应条件
iso-butyl nitrite; copper dichloride
T=40 - 55°C; Meerwein arylation; Large scale reaction;
参考文献
Maligres, Peter E.; Humphrey, Guy R.; Marcoux, Jean-Francois; Hillier, Michael C.; Zhao, Dalian; Krska, Shane; Grabowski, Edward J.J.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 525 - 534
