4-溴-7-甲基苯并[1,2,5]噻二唑合成路线 （共 5 条）
反应条件
N-bromosuccinmide; hydrogen bromide; dibenzoyl peroxide in tetrachloromethane; acetic acid 0.5 h; Heating;
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in chlorobenzene T=80°C; 4 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 133, # 40 p. 15822 - 15825
反应条件
hydrogen bromide; bromine
16 h; Heating;
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
1: 65 percent / thionyl chloride / benzene / 72 h
2: 86 percent / bromine; aq. HBr / 16 h / Heating
View Scheme
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
1: aq. HCl; SnCl2
2: 65 percent / thionyl chloride / benzene / 72 h
3: 86 percent / bromine; aq. HBr / 16 h / Heating
View Scheme
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
