4-溴-7-溴甲基苯并[1,2,5]噻二唑合成路线 （共 4 条）
反应条件
N-bromosuccinmide; hydrogen bromide; dibenzoyl peroxide in tetrachloromethane; acetic acid 0.5 h; Heating;
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
hydrogen bromide; bromine T=126 - 130°C;
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
1: 65 percent / thionyl chloride / benzene / 72 h 2: 86 percent / bromine; aq. HBr / 16 h / Heating 3: 97 percent / NBS; benzoyl peroxide; HBr / CCl4; acetic acid / 0.5 h / Heating View Scheme
参考文献
Pilgram,K. et al.
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 629 - 633
反应条件
1: aq. HCl; SnCl2 2: 65 percent / thionyl chloride / benzene / 72 h 3: 86 percent / bromine; aq. HBr / 16 h / Heating 4: 97 percent / NBS; benzoyl peroxide; HBr / CCl4; acetic acid / 0.5 h / Heating View Scheme
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
