二[4-(三氟甲基)苯基]甲醇合成路线 （共 7 条）
反应条件
1: 4-trifluoromethyl-1-iodobenzene With ethylmagnesium bromide in tetrahydrofuran T=25°C; 1 h; 2: 4-trifluoromethyl-benzaldehyde in tetrahydrofuran T=25°C; 17 h;
参考文献
Schering Corporation
Patent: WO2004/46111 A1, 2004 ;
Location in patent: Page 27-28 ;
反应条件
in tetrahydrofuran; hexane T=-78 - -65°C; 1.16667 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1437344 A1, 2004 ;
Location in patent: Page 50 ;
反应条件
1: 4-(trifluoromethyl)-benzyl bromide With magnesium; methyl iodide in diethyl ether 2.75 h; 2: α,α,α-trifluorotoluene in diethyl ether 1 h; 3: With hydrogenchloride; water
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/14847 A1, 2004 ;
Location in patent: Page 92 ;
WO 2004/014847 A1
反应条件
magnesium 1.) Et2O, 2.) Et2O, a) reflux, 1.5 h, b) RT, 16 h; Yield given. Multistep reaction;
参考文献
Hsieh, Tom H.H.; Dong, Vy M.
Tetrahedron, 2009 , vol. 65, # 16 p. 3062 - 3068
参考文献
Mills, Nancy S.; Benish, Michele A.; Ybarra, Christie
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2003 - 2012
反应条件
1: 72.6 percent / conc. H2SO4 / toluene / 2 h / 85 - 90 °C 2: 97.2 g / K2CO3 / acetonitrile / 15 h / Heating 3: 2 N aq. LiOH / methanol / 64 h / Ambient temperature View Scheme
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
反应条件
SbF5; epoxysulfonyl fluoride in various solvent(s) T=-78°C;
参考文献
Kelly, David P.; Jenkins, Margot J.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 409 - 413
