(R)-2-氨基-3-邻甲苯丙酸乙酯合成路线 （共 12 条）
反应条件
1: With lithium hydroxide monohydrate in ethanol; water T=25°C; 48 h; 2: With hydrogenchloride in ethanol; water pH=2; optical yield given as percent ee;
参考文献
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.
Organic Letters, 2009 , vol. 11, # 4 p. 807 - 810
反应条件
10 Pd/C; hydrogen in ethanol
T=20°C;
参考文献
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.
Organic Letters, 2009 , vol. 11, # 4 p. 807 - 810
反应条件
hydrogenchloride in water
3 h; Heating;
参考文献
Wu, Zhong-Liu; Li, Zu-Yi
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2133 - 2142
反应条件
in various solvent(s)
6 h; Ambient temperatureCandida lypolythica esterase;
参考文献
Yee, Christopher; Blythe, Todd A.; McNabb, Thomas J.; Walts, Alan E.
Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3525 - 3527
反应条件
1.1: K2CO3 / acetone / 20 °C
2.1: Rhodococcus sp. CGMCC 0497 / 24 h / 30 °C / pH 7.0
3.1: H2SO4 / H2O; ethanol / Heating
3.2: 98 percent / H2O2; NaOH / H2O; ethanol / 3 h / 20 °C
4.1: 98 percent / Hg(OAc)2; N-bromosuccinimide / dimethylformamide / 16 h / 20 °C
5.1: 89 percent / hydrochloric acid / H2O / 3 h / Heating
View Scheme
参考文献
Wu, Zhong-Liu; Li, Zu-Yi
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2133 - 2142
反应条件
1.1: Rhodococcus sp. CGMCC 0497 / 24 h / 30 °C / pH 7.0
2.1: H2SO4 / H2O; ethanol / Heating
2.2: 98 percent / H2O2; NaOH / H2O; ethanol / 3 h / 20 °C
3.1: 98 percent / Hg(OAc)2; N-bromosuccinimide / dimethylformamide / 16 h / 20 °C
4.1: 89 percent / hydrochloric acid / H2O / 3 h / Heating
View Scheme
参考文献
Wu, Zhong-Liu; Li, Zu-Yi
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2133 - 2142
反应条件
1: 3,4,5-F3-C6H2-NAS-Br; CsOH*H2O / toluene / -20 °C
2: aq. HCl / tetrahydrofuran
View Scheme
参考文献
Ooi, Takashi; Uematsu, Yukitaka; Maruoka, Keiji
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1675 - 1678
反应条件
1: 98 percent / Hg(OAc)2; N-bromosuccinimide / dimethylformamide / 16 h / 20 °C
2: 89 percent / hydrochloric acid / H2O / 3 h / Heating
View Scheme
参考文献
Wu, Zhong-Liu; Li, Zu-Yi
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2133 - 2142
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
1.) -78 deg C, 0.5 h, 2.) -78 deg C, 0.5 h; room temperature, overnight; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Antonov, Dmitri Yu.; Belokon, Yuri N.; Ikonnikov, Nikolai S.; Orlova, Svetlana A.; Pisarevsky, Aleksander P.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 14 p. 1873 - 1880
反应条件
phosphate buffer; Humicola amino esterase
Ambient temperature; Title compound not separated from byproducts;
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
