4-(Boc-氨基)环己醇合成路线 （共 19 条）
反应条件
triethylamine in tetrahydrofuran T=20°C;
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
Location in patent: Page/Page column 48-49 ;
反应条件
sodium hydroxide in water; tert-butyl alcohol T=20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 71 ;
EP 1403255 A1
反应条件
sodium hydroxide in 1,4-dioxane; water; ethyl acetate
参考文献
Showa Denko K.K.
Patent: US5166403 A1, 1992 ;
反应条件
sodium hydrogencarbonate in acetonitrile
参考文献
Pfizer Inc
Patent: US6156752 A1, 2000 ;
US 6156752 A
反应条件
triethylamine in tetrahydrofuran; ethyl acetate
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
sodium hydroxide in water T=20°C; 2 h;
参考文献
WO2004/43962 A1, ;
Page 37 ;
反应条件
1: trans-4-aminocyclohexanol hydrogenchloride With triethylamine in dichloromethane 0.5 h; 2: di-tert-butyl dicarbonate in dichloromethane T=0°C; 8 h;
参考文献
WO2005/21515 A2, ;
Page/Page column 72 ;
WO 2005/021515 A2
反应条件
triethylamine in dichloromethane; ethyl acetate
参考文献
US5726172 A1, ;
US 5726172 A
反应条件
triethylamine in tetrahydrofuran; methanol
参考文献
US2013/190249 A1, ;
Page/Page column ;
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
Madaiah; Prashanth; Revanasiddappa; Veeresh
Medicinal Chemistry Research, 2013 , vol. 22, # 6 p. 2633 - 2644
