2,2'-O-脱水-5-甲基尿嘧啶核苷合成路线 （共 43 条）
反应条件
in dichloromethane; 2-methoxy-ethanol; acetone; acetonitrile
参考文献
Isis Pharmaceuticals Inc.
Patent: US5958772 A1, 1999 ;
反应条件
tris(1,4-dioxapentane)borate; 2-methoxy-ethanol T=155 - 160°C; 48 h;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/9541 A2, 2004 ;
Location in patent: Page 52 ;
反应条件
T=155 - 160°C; 48 h;
参考文献
Bennett, C. Frank; Dobie, Kenneth W.; Jain, Ravi
Patent: US2005/107324 A1, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
in pyridine; methanol; dichloromethane; chloroform; 2-methoxy-ethanol; acetone; acetonitrile
参考文献
Isis Pharmaceuticals Inc.
Patent: US5981732 A1, 1999 ;
反应条件
in dichloromethane; 2-methoxy-ethanol; acetone; acetonitrile
参考文献
ISIS Pharmaceuticals, Inc.; Variagenics, Inc.
Patent: US6309882 B1, 2001 ;
反应条件
in dichloromethane; 2-methoxy-ethanol; acetone; acetonitrile
参考文献
ISIS Pharmaceuticals, Inc.
Patent: US6455307 B1, 2002 ;
反应条件
tris(1,4-dioxapentane)borate; sodium hydrogencarbonate T=130°C; 18 h; atmospheric pressure;
参考文献
Ross, Bruce S.; Song, Quanlai; Han, Mingming
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 815 - 818
反应条件
in dichloromethane; acetone; acetonitrile
参考文献
South Alabama Medical Science Foundation; ISIS Pharmaceuticals, Inc.
Patent: US5948902 A1, 1999 ;
反应条件
1: 1.) pyridine, 2.) NaOH / 1.) 60 deg C, 18 h, 2.) dioxane-methanol-water, room temperature overnight, reflux 30 min 3: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h 4: 100 percent / NaOH / dioxane View Scheme
参考文献
Herdewijn, P.; Aerschot, A. Van
Bulletin des Societes Chimiques Belges, 1989 , vol. 98, # 12 p. 943 - 948
反应条件
1: 1.) pyridine, 2.) NaOH / 1.) 60 deg C, 18 h, 2.) dioxane-methanol-water, room temperature overnight, reflux 30 min 3: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h 4: 100 percent / NaOH / dioxane 5: 64 percent / diethylaminosulfur trifluoride / CH2Cl2 / 8 h / Ambient temperature 6: 60 percent / 80percent acetic acid / 45 h / 60 °C View Scheme
参考文献
Herdewijn, P.; Aerschot, A. Van
Bulletin des Societes Chimiques Belges, 1989 , vol. 98, # 12 p. 943 - 948
