2,2'-O-脱水-5-甲基尿嘧啶核苷合成路线 （共 43 条）
反应条件
tris(1,4-dioxapentane)borate; sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232771 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
1: 85 percent / pyridinium bromide, pyridine / 3 h / Heating 2: 90 percent / H2 / Raney Ni / methanol / 2327.2 Torr View Scheme
参考文献
Rao, A. V. Rama; Gurjar, Mukund K.; Lalitha, Sista V. S.
Journal of the Chemical Society, Chemical Communications, 1994 , # 10 p. 1255 - 1256
反应条件
hydrogen fluoride in pyridine
参考文献
US2004/77567 A1, ;
Page/Page column 16 ;
反应条件
ammonium hydroxide T=70°C; 14 h;
参考文献
Sawai, Hiroaki; Hayashi, Hidekazu; Sekiguchi, Sumie
Chemistry Letters, 1994 , # 3 p. 605 - 606
反应条件
hydrogen fluoride in pyridine
参考文献
Isis Pharmaceuticals Inc.; Abbott Laboratories
Patent: US2004/77567 A1, 2004 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/225015 A1, 2003 ;
Location in patent: Page 18-19 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232770 A1, 2003 ;
Location in patent: Page 18 ;
反应条件
1: With sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h; 2: With water 0.5 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23384 A1, 2004 ;
Location in patent: Page/Page column 19 ;
反应条件
in 2-methoxy-ethanol T=155 - 160°C; 48 h;
参考文献
Isis Pharmaceuticals Inc.; Abbott Laboratories
Patent: US2004/77567 A1, 2004 ;
Location in patent: Page/Page column 16 ;
反应条件
tris(1,4-dioxapentane)borate; sodium hydrogencarbonate in 2-methoxy-ethanol T=130°C; 21 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232771 A1, 2003 ;
Location in patent: Page 19 ;
