2,2'-O-脱水-5-甲基尿嘧啶核苷合成路线 （共 43 条）
反应条件
carbonic acid diphenyl ester; sodium hydrogencarbonate in N,N-dimethyl-formamide T=100°C;
参考文献
Brown, Tom; El-Sagheer, Afaf Helmy
Patent: US2013/231473 A1, 2013 ;
Location in patent: Paragraph 0158 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 1 h; Heating / reflux;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/77085 A1, 2004 ;
Location in patent: Page/Page column 16 ;
反应条件
carbonic acid diphenyl ester; sodium carbonate in N,N-dimethyl-formamide T=110°C;
参考文献
MARINA BIOTECH INC.; MATRAY, Tracy J.; MACIAGIEWICZ, Iwona M.; HOUSTON, Michael E., Jr.
Patent: WO2013/36868 A1, 2013 ;
Location in patent: Page/Page column 30; 31 ;
反应条件
hydrogen bromide in ethanol; water; N,N-dimethyl-formamide
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=90°C; 5 h;
参考文献
Takatsuki, Ken-Ichi; Ohgushi, Sumito; Kohmoto, Shigeo; Kishikawa, Keiki; Yamamoto, Makoto
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 719 - 734
反应条件
sodium hydrogencarbonate in DMF (N,N-dimethyl-formamide) 1 h;
参考文献
WO2005/14607 A2, ;
Page/Page column 90-91 ;
反应条件
carbonic acid diphenyl ester; sodium hydrogencarbonate in N,N-dimethyl-formamide T=140 - 150°C; 4 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 10 p. 1255 - 1256
反应条件
1: 5.76 g / sodium methoxide / methanol / 20 °C 2: diphenyl carbonate; sodium hydrogen carbonate / dimethylformamide / 1.5 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 5 p. 749 - 752
反应条件
1: 14.36 g / trimethylsilyl chloride; hexamethyldisilazane; tin(IV) chloride / acetonitrile / 1.5 h / Heating 2: 5.76 g / sodium methoxide / methanol / 20 °C 3: diphenyl carbonate; sodium hydrogen carbonate / dimethylformamide / 1.5 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 5 p. 749 - 752
反应条件
1: 14.36 g / trimethylsilyl chloride; hexamethyldisilazane; tin(IV) chloride / acetonitrile / 1.5 h / Heating 2: 5.76 g / sodium methoxide / methanol / 20 °C 3: diphenyl carbonate; sodium hydrogen carbonate / dimethylformamide / 1.5 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 5 p. 749 - 752
