6-巯基嘌呤-2-脱氧核苷合成路线 （共 10 条）
反应条件
2: 2-chlorophenyl dichlorophosphate / Ambient temperature 3: thiolacetic acid / dioxane; H2O / 0 °C 4: 1M NaOH View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5837 - 5840
反应条件
1: 2-chlorophenyl dichlorophosphate / Ambient temperature 2: thiolacetic acid / dioxane; H2O / 0 °C 3: 1M NaOH View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5837 - 5840
反应条件
1: thiolacetic acid / dioxane; H2O / 0 °C 2: 1M NaOH View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5837 - 5840
反应条件
sodium hydroxide Yield given;
参考文献
Tetrahedron Letters, , vol. 33, # 39 p. 5837 - 5840
反应条件
hydrogen sulfide; sodium methylate 1) anhydr. MeOH, reflux, 2 h; 2) reflux, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1899 - 1903
反应条件
1: 61 percent / 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 30 min; 2) acetonitrile, 18 h 2: 1) H2S/1M sodium methoxide; 2) 1M sodium methoxide / 1) anhydr. MeOH, reflux, 2 h; 2) reflux, 1 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1899 - 1903
反应条件
1: 61 percent / 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 30 min; 2) acetonitrile, 18 h 2: 1) H2S/1M sodium methoxide; 2) 1M sodium methoxide / 1) anhydr. MeOH, reflux, 2 h; 2) reflux, 1 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1899 - 1903
反应条件
mit Hilfe von Purinnucleosid-Phosphorylase aus Leber;
参考文献
Biochimica et Biophysica Acta, , vol. 18, p. 447
反应条件
sodium hydroxide in methanol T=0 - 5°C; 2 h;
参考文献
Srivastava; Revankar; Robins; Rousseau
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 393 - 398
反应条件
human thiopurine S-methyltransferase expressed in yeast; tris(hydroxymethyl)methylamine hydrochloride T=21.5°C; Methylation; pH=7.4; 1 h; Enzymatic reaction; Enzyme kinetics;
参考文献
Krynetski, Eugene Y.; Krynetskaia, Natalia F.; Yanishevski, Yuri; Evans, William E.
Molecular Pharmacology, 1995 , vol. 47, # 6 p. 1141 - 1147
