(R)-(+)-α,α-二苯基脯氨醇合成路线 (共 61 条)
反应条件
hydrogen; acetic acid; palladium dihydroxide in methanol; dichloromethane T=20°C; P=760 Torr; 47 h;
参考文献
Nakano, Koji; Nozaki, Kyoko; Hiyama, Tamejiro
Journal of the American Chemical Society, 2003 , vol. 125, # 18 p. 5501 - 5510
反应条件
potassium hydroxide in methanol 4 h; Heating;
参考文献
Kanth, J. V. Bhaskar; Periasamy, Mariappan
Tetrahedron, 1993 , vol. 49, # 23 p. 5127 - 5132
反应条件
potassium hydroxide in methanol; dimethyl sulfoxide T=65°C; 4 h;
参考文献
Price, Michael D.; Kurth, Mark J.; Schore, Neil E.
Journal of Organic Chemistry, 2002 , vol. 67, # 22 p. 7769 - 7773
反应条件
sodium tetrahydroborate in methanol T=0 - 25°C; 0.583333 h;
参考文献
Periasamy, Mariappan; Sanjeevakumar, Nalluri; Dalai, Manasi; Gurubrahamam, Ramani; Reddy, Polimera Obula
Organic Letters, 2012 , vol. 14, # 12 p. 2932 - 2935
反应条件
1: in tetrahydrofuran T=20°C; Inert atmosphere; 2: With potassium hydroxide in methanol 16 h; RefluxInert atmosphere;
参考文献
Khong, San N.; Kwon, Ohyun
Molecules, 2012 , vol. 17, # 5 p. 5626 - 5650
反应条件
1: tetrahydrofuran / 20 h / 20 °C 2: 92 percent / H2; acetic acid / Pd(OH)2/C / CH2Cl2; methanol / 47 h / 20 °C / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 18 p. 5501 - 5510
反应条件
1.1: Mg; iodine / tetrahydrofuran / Heating 1.2: 45 percent / tetrahydrofuran / Heating 2.1: 15 percent / KOH / methanol / 4 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 6 p. 1082 - 1096
反应条件
1.1: 98 percent / K2CO3 / 12 h / 0 °C 2.1: Mg; iodine / tetrahydrofuran / Heating 2.2: 45 percent / tetrahydrofuran / Heating 3.1: 15 percent / KOH / methanol / 4 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 6 p. 1082 - 1096
反应条件
samarium diiodide; water in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 10, # 14 p. 3021 - 3023