2-氨基-5-硝基-6-甲基吡啶合成路线 （共 28 条）
反应条件
sulfuric acid; nitric acid T=0 - 100°C;
参考文献
KARO BIO AB; ELSY, David
Patent: WO2005/42464 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
WO 2005/042464 A1
反应条件
sulfuric acid; nitric acid
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: liquid NH3; xylene; Fe(NO3)3 2: concentrated H2SO4; concentrated HNO3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 69, p. 63,66
反应条件
sulfuric acid; nitric acid T=20 - 55°C; 2 h; Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 2 p. 727 - 739
反应条件
sulfuric acid; nitric acid
参考文献
Kulkarni, Santosh S.; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 2987 - 2991
参考文献
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 50, p. 536
Chem. Zentralbl., , vol. 94, # III p. 1022
反应条件
1: 97 percent / dimethylformamide / 24 h / 110 °C 2: H2 / 10 percent Pd/C / ethanol / 4 h / 20 °C / 2068.59 Torr View Scheme
参考文献
Filla, Sandra A.; Mathes, Brian M.; Johnson, Kirk W.; Phebus, Lee A.; Cohen, Marlene L.; Nelson, David L.; Zgombick, John M.; Erickson, Jon A.; Schenck, Kathryn W.; Wainscott, David B.; Branchek, Theresa A.; Schaus, John M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3060 - 3071
反应条件
1: 97 percent / dimethylformamide / 24 h / 110 °C 2: H2 / 10 percent Pd/C / ethanol / 4 h / 20 °C / 2068.59 Torr 3: 82 percent / KOH / methanol / 24 h / Heating 4: 88 percent / H2 / 10 percent Pd/C / ethanol; tetrahydrofuran / 24 h / 20 °C / 2068.59 Torr 5: pyridine / 55 °C View Scheme
参考文献
Filla, Sandra A.; Mathes, Brian M.; Johnson, Kirk W.; Phebus, Lee A.; Cohen, Marlene L.; Nelson, David L.; Zgombick, John M.; Erickson, Jon A.; Schenck, Kathryn W.; Wainscott, David B.; Branchek, Theresa A.; Schaus, John M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3060 - 3071
反应条件
1: aqueous sodium nitrite; aqueous sulfuric acid / Diazotization 2: phosphorus (V)-chloride; phosphoryl chloride 3: sodium acetate; ethanol; N2H4+H2O View Scheme
参考文献
Baumgarten; Su
Journal of the American Chemical Society, 1952 , vol. 74, p. 3828,3830
反应条件
sulfuric acid; water; sodium nitrite T=0 - 10°C; 1 h;
参考文献
KARO BIO AB; ELSY, David
Patent: WO2005/42464 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/042464 A1
